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Published online 18 November 2002. doi:10.1083/jcb.200204065
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© The Rockefeller University Press, 0021-9525/2002/11/571 $5.00
The Journal of Cell Biology, Volume 159, Number 4, 571-577

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Activation of myosin V–based motility and F-actin–dependent network formation of endoplasmic reticulum during mitosis



Torsten Wöllert1, Dieter G. Weiss1, Hans-Hermann Gerdes2 and Sergei A. Kuznetsov1,2

1 Institute of Cell Biology and Biosystems Technology, University of Rostock, D-18051 Rostock, Germany
2 Department of Neurobiology, Interdisciplinary Center of Neuroscience, University of Heidelberg, D-69120 Heidelberg, Germany

Address correspondence to Sergei A. Kuznetsov, Institute of Cell Biology and Biosystems Technology, University of Rostock, Albert-Einstein-Str. 3, D-18051 Rostock, Germany. Tel.: 49-381-498-6311. Fax: 49-381-498-6302. E-mail: Sergei.Kuznetsov{at}biologie.uni-rostock.de

It is widely believed that microtubule- and F-actin–based transport of cytoplasmic organelles and membrane fusion is down-regulated during mitosis. Here we show that during the transition of Xenopus egg extracts from interphase to metaphase myosin V–driven movement of small globular vesicles along F-actin is strongly inhibited. In contrast, the movement of ER and ER network formation on F-actin is up-regulated in metaphase extracts. Our data demonstrate that myosin V–driven motility of distinct organelles is differently controlled during the cell cycle and suggest an active role of F-actin in partitioning, positioning, and membrane fusion of the ER during cell division.

Key Words: cell cycle; organelle movement; Xenopus; oocyte; membrane fusion


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