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Published 3 February 2003. doi:10.1083/jcb.200301040
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© The Rockefeller University Press, 0021-9525/2003/2/291 $5.00
The Journal of Cell Biology, Volume 160, Number 3, 291-293

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Dynactin polices two-way organelle traffic



Karen R. Dell

Reviews Editor, The Journal of Cell Biology

Address correspondence to K.R. Dell, The Journal of Cell Biology, 1114 1st Ave., New York, NY 10021. Tel.: (415) 789-0982. Fax: (415) 476-5233. E-mail: kdell{at}itsa.ucsf.edu

How is the bidirectional motion of organelles controlled? In this issue, Deacon et al. (2003) reveal the unexpected finding that dynactin (previously known to control dynein-based motility) binds to kinesin II and regulates anterograde movement of Xenopus melanosomes. This result suggests that dynactin may be a key player in coordinating vesicle traffic in this system.


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