Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins

doi:10.1083/jcb.200207136

Published 18 February 2003. doi:10.1083/jcb.200207136

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© The Rockefeller University Press, 0021-9525/2003/2/475 $5.00
The Journal of Cell Biology, Volume 160, Number 4, 475-479

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Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca²⁺-handling proteins

S. Papp¹, E. Dziak¹, M. Michalak² and M. Opas¹

¹ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
² Canadian Institutes of Health Research, Membrane Protein Research Group, and the Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7

Address correspondence to S. Papp, Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8. Tel.: (416) 978-8947. E-mail: sylvia.papp{at}utoronto.ca

The endoplasmic reticulum is a heterogeneous compartment withrespect to the distribution of its Ca²⁺-handling proteins, namelythe Ca²⁺-binding proteins, the Ca²⁺ pumps and the Ca²⁺ releasechannels. The nonuniform distribution of these proteins mayexplain the functional heterogeneity of the endoplasmic reticulum,such as the generation of spatially complex Ca²⁺ signals, Ca²⁺homeostasis, and protein folding and quality control.

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