Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors

doi:10.1083/jcb.200301035

Published 17 March 2003. doi:10.1083/jcb.200301035

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© The Rockefeller University Press, 0021-9525/2003/3/811 $5.00
The Journal of Cell Biology, Volume 160, Number 6, 811-816

Mini-Review

Polarized growth and organelle segregation in yeast

: the tracks, motors, and receptors

Anthony Bretscher

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853

Address correspondence to Anthony Bretscher, Dept. of Molecular Biology and Genetics, Biotechnology Bldg., Cornell University, Ithaca, NY 14853. Tel.: (607) 255-5713. Fax: 607-255-6249. E-mail: apb5{at}cornell.edu

In yeast, growth and organelle segregation requires formin-dependentassembly of polarized actin cables. These tracks are used bymyosin Vs to deliver secretory vesicles for cell growth, organellesfor their segregation, and mRNA for fate determination. Severalspecific receptors have been identified that interact with thecargo-binding tails of the myosin Vs. A recent study implicatesspecific degradation in the bud of the vacuolar receptor, Vac17,as a mechanism for cell cycle–regulated segregation ofthis organelle.

Key Words: polarity; transport; actin; myosin; vacuole

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