Axonal transport of membranous and nonmembranous cargoes: a unified perspective

doi:10.1083/jcb.200212017

Published 17 March 2003. doi:10.1083/jcb.200212017

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© The Rockefeller University Press, 0021-9525/2003/3/817 $5.00
The Journal of Cell Biology, Volume 160, Number 6, 817-821

Mini-Review

Axonal transport of membranous and nonmembranous cargoes

: a unified perspective

Anthony Brown

Neurobiotechnology Center and Department of Neuroscience, The Ohio State University, Columbus, OH 43210

Address correspondence to Dr. Anthony Brown, The Ohio State University, Neurobiotechnology Center, Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210. Tel.: (614) 292-1205. Fax: (614) 292-5379. E-mail: brown.2302{at}osu.edu

Membranous and nonmembranous cargoes are transported along axonsin the fast and slow components of axonal transport, respectively.Recent observations on the movement of cytoskeletal polymersin axons suggest that slow axonal transport is generated byfast motors and that the slow rate is due to rapid movementsinterrupted by prolonged pauses. This supports a unified perspectivefor fast and slow axonal transport based on rapid movementsof diverse cargo structures that differ in the proportion ofthe time that they spend moving. A Flash feature (http://www.jcb.org/cgi/content/full/jcb.200212017/DC1)accompanies this Mini-Review.

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