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© The Rockefeller University Press, 0021-9525/2003/5/471 $5.00
The Journal of Cell Biology, Volume 161, Number 3, 471-476

Modeling network dynamics

José M.G. Vilar¹, Clin C. Guet^1,2 and Stanislas Leibler¹

¹ The Rockefeller University, New York, NY 10021
² Department of Molecular Biology, Princeton University, Princeton, NJ 08544

Address correspondence to José M.G. Vilar, The Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021. Tel.: (212) 327-7642. Fax: (212) 327-7640. E-mail: vilarj{at}rockefeller.edu

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

Key Words: gene expression; induction; lac operon; computational modeling; regulation

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