Caveolae/raft-dependent endocytosis

doi:10.1083/jcb.200302028

Published 27 May 2003. doi:10.1083/jcb.200302028

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© The Rockefeller University Press, 0021-9525/2003/5/673 $5.00
The Journal of Cell Biology, Volume 161, Number 4, 673-677

Mini-Review

Caveolae/raft-dependent endocytosis

Ivan R. Nabi and Phuong U. Le

Département de Pathologie et Biologie Cellulaire, Université de Montréal, Montreal, Quebec, Canada H3C 3J7

Address correspondence to Dr. Ivan R. Nabi, Département de Pathologie et Biologie Cellulaire, Université de Montréal, C.P. 6128, Succursale A, Montréal, Québec, Canada H3C 3J7. Tel.: (514) 343-6291. Fax: (514) 343-2459. E-mail: ivan.robert.nabi{at}umontreal.ca

Although caveolae are well-characterized subdomains of glycolipidrafts, their distinctive morphology and association with caveolinshas led to their internalization being considered differentfrom that of rafts. In this review, we propose that caveolaeand rafts are internalized via a common pathway, caveolae/raft-dependentendocytosis, defined by its clathrin independence, dynamin dependence,and sensitivity to cholesterol depletion. The regulatory roleof caveolin-1 and ligand sorting in this complex endocytic pathwayare specifically addressed.

Key Words: endocytosis; caveolae; glycolipid rafts; caveolin; dynamin

^* Abbreviations used in this paper: AMF, autocrine motility factor;CTX, cholera toxin; dynK44A, dynamin K44A mutant.

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