Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure

doi:10.1083/jcb.200301099

Published 23 June 2003. doi:10.1083/jcb.200301099

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© The Rockefeller University Press, 0021-9525/2003/6/1035 $5.00
The Journal of Cell Biology, Volume 161, Number 6, 1035-1040

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Yeast osmosensor Sln1 and plant cytokinin receptor Cre1 respond to changes in turgor pressure

Vladimír Reiser¹, Desmond C. Raitt¹ and Haruo Saito¹^,2

¹ Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
² Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan

Address correspondence to Dr. Haruo Saito, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115. Tel.: (617) 632-3814. Fax: (617) 632-5951. E-mail: h-saito{at}ims.u-tokyo.ac.jp

Very little is known about how cellular osmosensors monitorchanges in osmolarity of the environment. Here, we report thatin yeast, Sln1 osmosensor histidine kinase monitors changesin turgor pressures. Reductions in turgor caused by either hyperosmoticstress, nystatin, or removal of cell wall activate MAPK Hog1specifically through the SLN1 branch, but not through the SHO1branch of the high osmolarity glycerol pathway. The integrityof the periplasmic region of Sln1 was essential for its sensorfunction. We found that activity of the plant histidine kinasecytokinin response 1 (Cre1) is also regulated by changes inturgor pressure, in a manner identical to that of Sln1, in thepresence of cytokinin. We propose that Sln1 and Cre1 are turgorsensors, and that similar turgor-sensing mechanisms might regulatehyperosmotic stress responses both in yeast and plants.

Key Words: signal transduction; high osmolarity stress; histidine kinase; two-component system; HOG MAPK pathway

The online version of this article includes supplemental material.

^* Abbreviations used in this paper: Cre1, cytokinin response 1;HOG, high osmolarity glycerol; TM, transmembrane.

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