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© The Rockefeller University Press, 0021-9525/2003/10/203 $8.00
The Journal of Cell Biology, Volume 163, Number 2, 203-208

Sorting it out

Linton M. Traub

Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261

Address correspondence to Linton M. Traub, Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261. Tel.: (412) 648-9713. Fax: (412) 648-9095. email: traub{at}pitt.edu

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.

Key Words: endocytosis; sorting; clathrin; cargo; AP-2

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