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Published 27 October 2003. doi:10.1083/jcb.200308082
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© The Rockefeller University Press, 0021-9525/2003/10/209 $8.00
The Journal of Cell Biology, Volume 163, Number 2, 209-213


Mini-Review

Lymphatic endothelium

: morphological, molecular and functional properties



Michael S. Pepper1 and Mihaela Skobe2

1 Department of Morphology, University Medical Center, 1206 Geneva, Switzerland
2 Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029

Address correspondence to Mihaela Skobe, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1130, New York, NY 10029. Tel.: (212) 659-5570. Fax: (212) 987-2240. email: mihaela.skobe{at}mssm.edu

The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged. This overview highlights recent advances in our understanding of the molecular mechanisms underlying the formation and function of lymphatic vessels.


Abbreviations used in this paper: BEC, blood endothelial cell; CCL, chemokine ligand; CCR, chemokine receptor; CLEVER-1, common lymphatic endothelial and vascular endothelial receptor-1; LEC, lymphatic endothelial cell; MR, mannose receptor; VEGF, vascular endothelial growth factor.


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