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© The Rockefeller University Press, 0021-9525/2003/10/209 $8.00
The Journal of Cell Biology, Volume 163, Number 2, 209-213

Lymphatic endothelium

Michael S. Pepper¹ and Mihaela Skobe²

¹ Department of Morphology, University Medical Center, 1206 Geneva, Switzerland
² Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029

Address correspondence to Mihaela Skobe, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1130, New York, NY 10029. Tel.: (212) 659-5570. Fax: (212) 987-2240. email: mihaela.skobe{at}mssm.edu

The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged. This overview highlights recent advances in our understanding of the molecular mechanisms underlying the formation and function of lymphatic vessels.

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