Lymphatic endothelium: morphological, molecular and functional properties

doi:10.1083/jcb.200308082

Published 27 October 2003. doi:10.1083/jcb.200308082

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© The Rockefeller University Press, 0021-9525/2003/10/209 $8.00
The Journal of Cell Biology, Volume 163, Number 2, 209-213

Mini-Review

Lymphatic endothelium

: morphological, molecular and functional properties

Michael S. Pepper¹ and Mihaela Skobe²

¹ Department of Morphology, University Medical Center, 1206 Geneva, Switzerland
² Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, NY 10029

Address correspondence to Mihaela Skobe, Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1130, New York, NY 10029. Tel.: (212) 659-5570. Fax: (212) 987-2240. email: mihaela.skobe{at}mssm.edu

The lymphatic microvasculature is uniquely adapted for the continuousremoval of interstitial fluid and proteins, and is an importantpoint of entry for leukocytes and tumor cells. The traditionalview that lymphatic capillaries are passive participants inthese tasks is currently being challenged. This overview highlightsrecent advances in our understanding of the molecular mechanismsunderlying the formation and function of lymphatic vessels.

Abbreviations used in this paper: BEC, blood endothelial cell;CCL, chemokine ligand; CCR, chemokine receptor; CLEVER-1, commonlymphatic endothelial and vascular endothelial receptor-1; LEC,lymphatic endothelial cell; MR, mannose receptor; VEGF, vascularendothelial growth factor.

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