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Published 10 November 2003. doi:10.1083/jcb.200310090
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© The Rockefeller University Press, 0021-9525/2003/11/437 $8.00
The Journal of Cell Biology, Volume 163, Number 3, 437-440

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: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells



Mark Peifer1 and Alpha S. Yap2

1 Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
2 Institute for Molecular Bioscience and School for Biomedical Science, University of Queensland, St. Lucia, Brisbane, Australia 4072

Address correspondence to Mark Peifer, Department of Biology, Coker Hall, CB #3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280. Tel.: (919) 962-2271. Fax: (919) 962-1625. email: peifer{at}unc.edu

Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking (Chen et al., 2003; Davis et al., 2003; Xiao et al., 2003).

Abbreviations used in this paper: JM, juxtamembrane; siRNA, small interfering RNA.


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