Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

doi:10.1083/jcb.200305129

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Published 10 November 2003. doi:10.1083/jcb.200305129

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© The Rockefeller University Press, 0021-9525/2003/11/463 $8.00
The Journal of Cell Biology, Volume 163, Number 3, 463-468

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Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Tiziana Bisogno¹, Fiona Howell², Gareth Williams², Alberto Minassi¹, Maria Grazia Cascio¹, Alessia Ligresti¹, Isabel Matias¹, Aniello Schiano-Moriello¹, Praveen Paul², Emma-Jane Williams², Uma Gangadharan², Carl Hobbs², Vincenzo Di Marzo¹ and Patrick Doherty²

¹ Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, 80078 Pozzuoli, Italy
² Molecular Neurobiology Group, Medical Research Council Centre for Developmental Neurobiology, King's College London, London Bridge, London SE1 1UL, UK

Address correspondence to Patrick Doherty, Molecular Neurobiology Group, Medical Research Council Center for Developmental Neurobiology, New Hunt's House, King's College London, London Bridge, London SE1 1UL, UK. Tel.: 44-207-848-6813. Fax: 44-207-848-6816. email: patrick.doherty{at}kcl.ac.uk; or Vincenzo Di Marzo, Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Italy. Tel.: 39-081-8675093. Fax: 39-081-8041770. email: vdimarzo{at}icmib.na.cnr.it

Diacylglycerol (DAG) lipase activity is required for axonalgrowth during development and for retrograde synaptic signalingat mature synapses. This enzyme synthesizes the endocannabinoid2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptoris also required for the above responses. We now report on thecloning and enzymatic characterization of the first specificsn-1 DAG lipases. Two closely related genes have been identifiedand their expression in cells correlated with 2-AG biosynthesisand release. The expression of both enzymes changes from axonaltracts in the embryo to dendritic fields in the adult, and thiscorrelates with the developmental change in requirement for2-AG synthesis from the pre- to the postsynaptic compartment.This switch provides a possible explanation for a fundamentalchange in endocannabinoid function during brain development.Identification of these enzymes may offer new therapeutic opportunitiesfor a wide range of disorders.

Key Words: diacylglycerol lipase; CB1 receptor; anandamide; axonal growth; synaptic plasticity

T. Bisogno, F. Howell, and G. Williams contributed equally tothis work.

Abbreviations used in this paper: 2-AG, 2-arachidonoyl-glycerol;BDNF, brain-derived neuronotrophic factor; DAGL, DAG lipase;THL, tetrahydrolipstatin.

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