A core function for p120-catenin in cadherin turnover

doi:10.1083/jcb.200307111

Published 10 November 2003. doi:10.1083/jcb.200307111

This Article

Full Text

Full Text (PDF, 372K)

PPT slides of all figures

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JCB

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Davis, M. A.

Articles by Reynolds, A. B.

Search for Related Content

PubMed

PubMed Citation

Articles by Davis, M. A.

Articles by Reynolds, A. B.

Pubmed/NCBI databases

Gene	GEO Profiles
HomoloGene	UniGene

Social Bookmarking

What's this?

© The Rockefeller University Press, 0021-9525/2003/11/525 $8.00
The Journal of Cell Biology, Volume 163, Number 3, 525-534

Article

A core function for p120-catenin in cadherin turnover

Michael A. Davis, Renee C. Ireton and Albert B. Reynolds

Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232

Address correspondence to Albert B. Reynolds, Dept. of Cancer Biology, 771 PRB, 2220 Pierce Ave., Nashville, TN 37232-6840. Tel.: (615) 343-9532. Fax: (615) 936-6399. email: al.reynolds{at}mcmail.vanderbilt.edu

p120-catenin stabilizes epithelial cadherin (E-cadherin) inSW48 cells, but the mechanism has not been established. Here,we show that p120 acts at the cell surface to control cadherinturnover, thereby regulating cadherin levels. p120 knockdownby siRNA expression resulted in dose-dependent elimination ofepithelial, placental, neuronal, and vascular endothelial cadherins,and complete loss of cell–cell adhesion. ARVCF and ${delta}$ -cateninwere functionally redundant, suggesting that proper cadherin-dependentadhesion requires the presence of at least one p120 family member.The data reveal a core function of p120 in cadherin complexes,and strongly predict a dose-dependent loss of E-cadherin intumors that partially or completely down-regulate p120.

Key Words: tumor suppressor; p120-catenin; cell adhesion; tumor progression; metastasis

M.A. Davis and R.C. Ireton contributed equally to this paper.

Abbreviations used in this paper: E-cadherin, epithelial cadherin;h siRNA, human small interfering RNA; HUAEC, human umbilicalaortic endothelial cells; m siRNA, murine small interferingRNA; N-cadherin, neuronal cadherin; p120, p120-catenin; P-cadherin,placental cadherin; pRS, pRetroSuper; siRNA, small interferingRNA; VE-cadherin, vascular endothelial cadherin.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Chun, J., Prince, A. (2009). Ca2+ signaling in airway epithelial cells facilitates leukocyte recruitment and transepithelial migration. J. Leukoc. Biol. 86: 1135-1144 [Abstract] [Full Text]
Deplazes, J., Fuchs, M., Rauser, S., Genth, H., Lengyel, E., Busch, R., Luber, B. (2009). Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation. Hum Mol Genet 18: 3632-3644 [Abstract] [Full Text]
Shapiro, L., Weis, W. I. (2009). Structure and Biochemistry of Cadherins and Catenins. Cold Spring Harb. Perspect. Biol. 1: a003053-a003053 [Abstract] [Full Text]
Taulet, N., Comunale, F., Favard, C., Charrasse, S., Bodin, S., Gauthier-Rouviere, C. (2009). N-cadherin/p120 Catenin Association at Cell-Cell Contacts Occurs in Cholesterol-rich Membrane Domains and Is Required for RhoA Activation and Myogenesis. J. Biol. Chem. 284: 23137-23145 [Abstract] [Full Text]
Zhou, Q., Yan, B., Hu, X., Li, X.-B., Zhang, J., Fang, J. (2009). Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Molecular Cancer Therapeutics 8: 1684-1691 [Abstract] [Full Text]
Arikkath, J., Peng, I-F., Gie Ng, Y., Israely, I., Liu, X., Ullian, E. M., Reichardt, L. F. (2009). {delta}-Catenin Regulates Spine and Synapse Morphogenesis and Function in Hippocampal Neurons during Development. J. Neurosci. 29: 5435-5442 [Abstract] [Full Text]
de Beco, S., Gueudry, C., Amblard, F., Coscoy, S. (2009). Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc. Natl. Acad. Sci. USA 106: 7010-7015 [Abstract] [Full Text]
Keil, R., Kiessling, C., Hatzfeld, M. (2009). Targeting of p0071 to the midbody depends on KIF3. J. Cell Sci. 122: 1174-1183 [Abstract] [Full Text]
Chiasson, C. M., Wittich, K. B., Vincent, P. A., Faundez, V., Kowalczyk, A. P. (2009). p120-Catenin Inhibits VE-Cadherin Internalization through a Rho-independent Mechanism. Mol. Biol. Cell 20: 1970-1980 [Abstract] [Full Text]
Dohn, M. R., Brown, M. V., Reynolds, A. B. (2009). An essential role for p120-catenin in Src- and Rac1-mediated anchorage-independent cell growth. JCB 184: 437-450 [Abstract] [Full Text]
Kouchi, Z., Barthet, G., Serban, G., Georgakopoulos, A., Shioi, J., Robakis, N. K. (2009). p120 Catenin Recruits Cadherins to {gamma}-Secretase and Inhibits Production of A{beta} Peptide. J. Biol. Chem. 284: 1954-1961 [Abstract] [Full Text]
Abu-Elneel, K., Ochiishi, T., Medina, M., Remedi, M., Gastaldi, L., Caceres, A., Kosik, K. S. (2008). A {delta}-Catenin Signaling Pathway Leading to Dendritic Protrusions. J. Biol. Chem. 283: 32781-32791 [Abstract] [Full Text]
Soto, E., Yanagisawa, M., Marlow, L. A., Copland, J. A., Perez, E. A., Anastasiadis, P. Z. (2008). p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression. JCB 183: 737-749 [Abstract] [Full Text]
Perez-Moreno, M., Song, W., Pasolli, H. A., Williams, S. E., Fuchs, E. (2008). From the Cover: Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc. Natl. Acad. Sci. USA 105: 15399-15404 [Abstract] [Full Text]
Zahn, C., Jaschke, A., Weiske, J., Hommel, A., Hesse, D., Augustin, R., Lu, L., Hong, W., Florian, S., Scheepers, A., Joost, H.-G., Huber, O., Schurmann, A. (2008). ADP-ribosylation Factor-like GTPase ARFRP1 Is Required for Trans-Golgi to Plasma Membrane Trafficking of E-cadherin. J. Biol. Chem. 283: 27179-27188 [Abstract] [Full Text]
Ogden, S. R., Wroblewski, L. E., Weydig, C., Romero-Gallo, J., O'Brien, D. P., Israel, D. A., Krishna, U. S., Fingleton, B., Reynolds, A. B., Wessler, S., Peek, R. M. Jr (2008). p120 and Kaiso Regulate Helicobacter pylori-induced Expression of Matrix Metalloproteinase-7. Mol. Biol. Cell 19: 4110-4121 [Abstract] [Full Text]
Hirano, M., Hashimoto, S., Yonemura, S., Sabe, H., Aizawa, S. (2008). EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. JCB 182: 1217-1230 [Abstract] [Full Text]
Zhu, Y.-T., Hayashida, Y., Kheirkhah, A., He, H., Chen, S.-Y., Tseng, S. C. G. (2008). Characterization and Comparison of Intercellular Adherent Junctions Expressed by Human Corneal Endothelial Cells In Vivo and In Vitro. IOVS 49: 3879-3886 [Abstract] [Full Text]
Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C. M., Cheville, J. C., Parker, A. S., Copland, J. A., Anastasiadis, P. Z. (2008). A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease. J. Biol. Chem. 283: 18344-18354 [Abstract] [Full Text]
Bard, L., Boscher, C., Lambert, M., Mege, R.-M., Choquet, D., Thoumine, O. (2008). A Molecular Clutch between the Actin Flow and N-Cadherin Adhesions Drives Growth Cone Migration. J. Neurosci. 28: 5879-5890 [Abstract] [Full Text]
Mruk, D. D., Silvestrini, B., Cheng, C. Y. (2008). Anchoring Junctions As Drug Targets: Role in Contraceptive Development. Pharmacol. Rev. 60: 146-180 [Abstract] [Full Text]
Bibert, S., Ayari, H., Riveline, D., Concord, E., Hermant, B., Vernet, T., Gulino-Debrac, D. (2008). Establishment of cell-cell junctions depends on the oligomeric states of VE-cadherin. J Biochem 143: 821-832 [Abstract] [Full Text]
Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y., Johnson, K. R. (2008). Cadherin switching. J. Cell Sci. 121: 727-735 [Abstract] [Full Text]
Miyashita, Y., Ozawa, M. (2007). A dileucine motif in its cytoplasmic domain directs -catenin-uncoupled E-cadherin to the lysosome. J. Cell Sci. 120: 4395-4406 [Abstract] [Full Text]
Komarova, Y. A., Mehta, D., Malik, A. B. (2007). Dual Regulation of Endothelial Junctional Permeability. Sci Signal 2007: re8-re8 [Abstract] [Full Text]
Daugherty, R. L., Gottardi, C. J. (2007). Phospho-regulation of {beta}-Catenin Adhesion and Signaling Functions. Physiology 22: 303-309 [Abstract] [Full Text]
Allingham, M. J., van Buul, J. D., Burridge, K. (2007). ICAM-1-Mediated, Src- and Pyk2-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation Is Required for Leukocyte Transendothelial Migration. J. Immunol. 179: 4053-4064 [Abstract] [Full Text]
Aguilera, O., Pena, C., Garcia, J. M., Larriba, M. J., Ordonez-Moran, P., Navarro, D., Barbachano, A., Lopez de Silanes, I., Ballestar, E., Fraga, M. F., Esteller, M., Gamallo, C., Bonilla, F., Gonzalez-Sancho, J. M., Munoz, A. (2007). The Wnt antagonist DICKKOPF-1 gene is induced by 1{alpha},25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis 28: 1877-1884 [Abstract] [Full Text]
Sampson, H. W., Dearman, A. C., Akintola, A. D., Zimmer, W. E., Parrish, A. R. (2007). Immunohistochemical Localization of Cadherin and Catenin Adhesion Molecules in the Murine Growth Plate. J. Histochem. Cytochem. 55: 845-852 [Abstract] [Full Text]
Tao, Q., Nandadasa, S., McCrea, P. D., Heasman, J., Wylie, C. (2007). G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development 134: 2651-2661 [Abstract] [Full Text]
Ezaki, T., Guo, R.-J., Li, H., Reynolds, A. B., Lynch, J. P. (2007). The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G54-G65 [Abstract] [Full Text]
Ichii, T., Takeichi, M. (2007). p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner. GENES CELLS 12: 827-839 [Abstract] [Full Text]
Boguslavsky, S., Grosheva, I., Landau, E., Shtutman, M., Cohen, M., Arnold, K., Feinstein, E., Geiger, B., Bershadsky, A. (2007). p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc. Natl. Acad. Sci. USA 104: 10882-10887 [Abstract] [Full Text]
Bryant, D. M., Kerr, M. C., Hammond, L. A., Joseph, S. R., Mostov, K. E., Teasdale, R. D., Stow, J. L. (2007). EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J. Cell Sci. 120: 1818-1828 [Abstract] [Full Text]
Hosking, C. R., Ulloa, F., Hogan, C., Ferber, E. C., Figueroa, A., Gevaert, K., Birchmeier, W., Briscoe, J., Fujita, Y. (2007). The Transcriptional Repressor Glis2 Is a Novel Binding Partner for p120 Catenin. Mol. Biol. Cell 18: 1918-1927 [Abstract] [Full Text]
Miyashita, Y., Ozawa, M. (2007). Increased Internalization of p120-uncoupled E-cadherin and a Requirement for a Dileucine Motif in the Cytoplasmic Domain for Endocytosis of the Protein. J. Biol. Chem. 282: 11540-11548 [Abstract] [Full Text]
Xie, Z., Bikle, D. D. (2007). The Recruitment of Phosphatidylinositol 3-Kinase to the E-cadherin-Catenin Complex at the Plasma Membrane Is Required for Calcium-induced Phospholipase C-{gamma}1 Activation and Human Keratinocyte Differentiation. J. Biol. Chem. 282: 8695-8703 [Abstract] [Full Text]
Kooistra, M. R. H., Dube, N., Bos, J. L. (2007). Rap1: a key regulator in cell-cell junction formation. J. Cell Sci. 120: 17-22 [Abstract] [Full Text]
Capaldo, C. T., Macara, I. G. (2007). Depletion of E-Cadherin Disrupts Establishment but Not Maintenance of Cell Junctions in Madin-Darby Canine Kidney Epithelial Cells. Mol. Biol. Cell 18: 189-200 [Abstract] [Full Text]
Shtutman, M., Levina, E., Ohouo, P., Baig, M., Roninson, I. B. (2006). Cell Adhesion Molecule L1 Disrupts E-Cadherin-Containing Adherens Junctions and Increases Scattering and Motility of MCF7 Breast Carcinoma Cells. Cancer Res. 66: 11370-11380 [Abstract] [Full Text]
Halbleib, J. M., Nelson, W. J. (2006). Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 20: 3199-3214 [Abstract] [Full Text]
Weis, W. I., Nelson, W. J. (2006). Re-solving the Cadherin-Catenin-Actin Conundrum. J. Biol. Chem. 281: 35593-35597 [Full Text]
Brantley-Sieders, D. M., Fang, W. B., Hwang, Y., Hicks, D., Chen, J. (2006). Ephrin-A1 Facilitates Mammary Tumor Metastasis through an Angiogenesis-Dependent Mechanism Mediated by EphA Receptor and Vascular Endothelial Growth Factor in Mice. Cancer Res. 66: 10315-10324 [Abstract] [Full Text]
Yanagisawa, M., Anastasiadis, P. Z. (2006). p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness. JCB 174: 1087-1096 [Abstract] [Full Text]
Hou, J. C., Shigematsu, S., Crawford, H. C., Anastasiadis, P. Z., Pessin, J. E. (2006). Dual Regulation of Rho and Rac by p120 Catenin Controls Adipocyte Plasma Membrane Trafficking. J. Biol. Chem. 281: 23307-23312 [Abstract] [Full Text]
Youn, Y.-H., Hong, J., Burke, J. M. (2006). Cell Phenotype in Normal Epithelial Cell Lines with High Endogenous N-Cadherin: Comparison of RPE to an MDCK Subclone.. IOVS 47: 2675-2685 [Abstract] [Full Text]
Kiener, H. P., Stipp, C. S., Allen, P. G., Higgins, J. M.G., Brenner, M. B. (2006). The Cadherin-11 Cytoplasmic Juxtamembrane Domain Promotes {alpha}-Catenin Turnover at Adherens Junctions and Intercellular Motility. Mol. Biol. Cell 17: 2366-2376 [Abstract] [Full Text]
Calkins, C. C., Setzer, S. V., Jennings, J. M., Summers, S., Tsunoda, K., Amagai, M., Kowalczyk, A. P. (2006). Desmoglein Endocytosis and Desmosome Disassembly Are Coordinated Responses to Pemphigus Autoantibodies. J. Biol. Chem. 281: 7623-7634 [Abstract] [Full Text]
Hofmann, I., Casella, M., Schnolzer, M., Schlechter, T., Spring, H., Franke, W. W. (2006). Identification of the Junctional Plaque Protein Plakophilin 3 in Cytoplasmic Particles Containing RNA-binding Proteins and the Recruitment of Plakophilins 1 and 3 to Stress Granules. Mol. Biol. Cell 17: 1388-1398 [Abstract] [Full Text]
Sato, T., Fujita, N., Yamada, A., Ooshio, T., Okamoto, R., Irie, K., Takai, Y. (2006). Regulation of the Assembly and Adhesion Activity of E-cadherin by Nectin and Afadin for the Formation of Adherens Junctions in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 281: 5288-5299 [Abstract] [Full Text]
Charrasse, S., Comunale, F., Grumbach, Y., Poulat, F., Blangy, A., Gauthier-Rouviere, C. (2006). RhoA GTPase Regulates M-Cadherin Activity and Myoblast Fusion. Mol. Biol. Cell 17: 749-759 [Abstract] [Full Text]
Thoumine, O., Lambert, M., Mege, R.-M., Choquet, D. (2006). Regulation of N-Cadherin Dynamics at Neuronal Contacts by Ligand Binding and Cytoskeletal Coupling. Mol. Biol. Cell 17: 862-875 [Abstract] [Full Text]
Fox, D. T., Homem, C. C. F., Myster, S. H., Wang, F., Bain, E. E., Peifer, M. (2005). Rho1 regulates Drosophila adherens junctions independently of p120ctn. Development 132: 4819-4831 [Abstract] [Full Text]
Xiao, K., Garner, J., Buckley, K. M., Vincent, P. A., Chiasson, C. M., Dejana, E., Faundez, V., Kowalczyk, A. P. (2005). p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin. Mol. Biol. Cell 16: 5141-5151 [Abstract] [Full Text]
Van Marck, V., Stove, C., Van Den Bossche, K., Stove, V., Paredes, J., Vander Haeghen, Y., Bracke, M. (2005). P-Cadherin Promotes Cell-Cell Adhesion and Counteracts Invasion in Human Melanoma. Cancer Res. 65: 8774-8783 [Abstract] [Full Text]
Hoshino, T., Sakisaka, T., Baba, T., Yamada, T., Kimura, T., Takai, Y. (2005). Regulation of E-cadherin Endocytosis by Nectin through Afadin, Rap1, and p120ctn. J. Biol. Chem. 280: 24095-24103 [Abstract] [Full Text]
Wei, C.-J., Francis, R., Xu, X., Lo, C. W. (2005). Connexin43 Associated with an N-cadherin-containing Multiprotein Complex Is Required for Gap Junction Formation in NIH3T3 Cells. J. Biol. Chem. 280: 19925-19936 [Abstract] [Full Text]
Smalley, K. S.M., Brafford, P., Haass, N. K., Brandner, J. M., Brown, E., Herlyn, M. (2005). Up-Regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-Cadherin and Contributes to Invasion and Adhesion. Am. J. Pathol. 166: 1541-1554 [Abstract] [Full Text]
Luo, Y., Radice, G. L. (2005). N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. JCB 169: 29-34 [Abstract] [Full Text]
Tricaud, N., Perrin-Tricaud, C., Bruses, J. L., Rutishauser, U. (2005). Adherens Junctions in Myelinating Schwann Cells Stabilize Schmidt-Lanterman Incisures via Recruitment of p120 Catenin to E-Cadherin. J. Neurosci. 25: 3259-3269 [Abstract] [Full Text]
Soubry, A., van Hengel, J., Parthoens, E., Colpaert, C., Van Marck, E., Waltregny, D., Reynolds, A. B., van Roy, F. (2005). Expression and Nuclear Location of the Transcriptional Repressor Kaiso Is Regulated by the Tumor Microenvironment. Cancer Res. 65: 2224-2233 [Abstract] [Full Text]
Haas, I. G., Frank, M., Veron, N., Kemler, R. (2005). Presenilin-dependent Processing and Nuclear Function of {gamma}-Protocadherins. J. Biol. Chem. 280: 9313-9319 [Abstract] [Full Text]
Koop, E. A., Gebbink, M. F. B. G., Sweeney, T. E., Mathy, M.-J., Heijnen, H. F. G., Spaan, J. A. E., Voest, E. E., VanBavel, E., Peters, S. L. M. (2005). Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-{micro}-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 288: H1218-H1223 [Abstract] [Full Text]
Wang, E., Ngalame, Y., Panelli, M. C., Nguyen-Jackson, H., Deavers, M., Mueller, P., Hu, W., Savary, C. A., Kobayashi, R., Freedman, R. S., Marincola, F. M. (2005). Peritoneal and Subperitoneal Stroma May Facilitate Regional Spread of Ovarian Cancer. Clin. Cancer Res. 11: 113-122 [Abstract] [Full Text]
Bryant, D. M., Wylie, F. G., Stow, J. L. (2005). Regulation of Endocytosis, Nuclear Translocation, and Signaling of Fibroblast Growth Factor Receptor 1 by E-Cadherin. Mol. Biol. Cell 16: 14-23 [Abstract] [Full Text]
Kausalya, P. J., Phua, D. C.Y., Hunziker, W. (2004). Association of ARVCF with Zonula Occludens (ZO)-1 and ZO-2: Binding to PDZ-Domain Proteins and Cell-Cell Adhesion Regulate Plasma Membrane and Nuclear Localization of ARVCF. Mol. Biol. Cell 15: 5503-5515 [Abstract] [Full Text]
Paredes, J., Stove, C., Stove, V., Milanezi, F., Van Marck, V., Derycke, L., Mareel, M., Bracke, M., Schmitt, F. (2004). P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells. Cancer Res. 64: 8309-8317 [Abstract] [Full Text]
Jontes, J. D., Emond, M. R., Smith, S. J (2004). In Vivo Trafficking and Targeting of N-Cadherin to Nascent Presynaptic Terminals. J. Neurosci. 24: 9027-9034 [Abstract] [Full Text]
Fouquet, S., Lugo-Martinez, V.-H., Faussat, A.-M., Renaud, F., Cardot, P., Chambaz, J., Pincon-Raymond, M., Thenet, S. (2004). Early Loss of E-cadherin from Cell-Cell Contacts Is Involved in the Onset of Anoikis in Enterocytes. J. Biol. Chem. 279: 43061-43069 [Abstract] [Full Text]
Jordan, B. A., Fernholz, B. D., Boussac, M., Xu, C., Grigorean, G., Ziff, E. B., Neubert, T. A. (2004). Identification and Verification of Novel Rodent Postsynaptic Density Proteins. Mol. Cell. Proteomics 3: 857-871 [Abstract] [Full Text]
Gavard, J., Marthiens, V., Monnet, C., Lambert, M., Mege, R. M. (2004). N-cadherin Activation Substitutes for the Cell Contact Control in Cell Cycle Arrest and Myogenic Differentiation: INVOLVEMENT OF p120 AND {beta}-CATENIN. J. Biol. Chem. 279: 36795-36802 [Abstract] [Full Text]
Jaffer, Z. M., Chernoff, J. (2004). The Cross-Rho'ds of Cell-Cell Adhesion. J. Biol. Chem. 279: 35123-35126 [Full Text]
Ciesiolka, M., Delvaeye, M., Van Imschoot, G., Verschuere, V., McCrea, P., van Roy, F., Vleminckx, K. (2004). p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. J. Cell Sci. 117: 4325-4339 [Abstract] [Full Text]
Izumi, G., Sakisaka, T., Baba, T., Tanaka, S., Morimoto, K., Takai, Y. (2004). Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. JCB 166: 237-248 [Abstract] [Full Text]
Krakstad, B. F., Ardawatia, V. V., Aragay, A. M. (2004). A role for G{alpha}12/G{alpha}13 in p120ctn regulation. Proc. Natl. Acad. Sci. USA 101: 10314-10319 [Abstract] [Full Text]
Xu, G., Craig, A. W. B., Greer, P., Miller, M., Anastasiadis, P. Z., Lilien, J., Balsamo, J. (2004). Continuous association of cadherin with {beta}-catenin requires the non-receptor tyrosine-kinase Fer. J. Cell Sci. 117: 3207-3219 [Abstract] [Full Text]
Mehta, D. (2004). p120: the guardian of endothelial junctional integrity. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L1140-L1142 [Full Text]
Shibata, T., Kokubu, A., Sekine, S., Kanai, Y., Hirohashi, S. (2004). Cytoplasmic p120ctn Regulates the Invasive Phenotypes of E-Cadherin-Deficient Breast Cancer. Am. J. Pathol. 164: 2269-2278 [Abstract] [Full Text]
Iyer, S., Ferreri, D. M., DeCocco, N. C., Minnear, F. L., Vincent, P. A. (2004). VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L1143-L1153 [Abstract] [Full Text]
Vincent, P. A., Xiao, K., Buckley, K. M., Kowalczyk, A. P. (2004). VE-cadherin: adhesion at arm's length. Am. J. Physiol. Cell Physiol. 286: C987-C997 [Abstract] [Full Text]
Fang, X., Ji, H., Kim, S.-W., Park, J.-I., Vaught, T. G., Anastasiadis, P. Z., Ciesiolka, M., McCrea, P. D. (2004). Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. JCB 165: 87-98 [Abstract] [Full Text]
Murray, R. Z., Jolly, L. A., Wood, S. A. (2004). The FAM Deubiquitylating Enzyme Localizes to Multiple Points of Protein Trafficking in Epithelia, where It Associates with E-cadherin and {beta}-catenin. Mol. Biol. Cell 15: 1591-1599 [Abstract] [Full Text]
Mariner, D. J., Davis, M. A., Reynolds, A. B. (2004). EGFR signaling to p120-catenin through phosphorylation at Y228. J. Cell Sci. 117: 1339-1350 [Abstract] [Full Text]
Nelson, W. J., Nusse, R. (2004). Convergence of Wnt, {beta}-Catenin, and Cadherin Pathways. Science 303: 1483-1487 [Abstract] [Full Text]
Peifer, M., Yap, A. S. (2003). Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells. JCB 163: 437-440 [Abstract] [Full Text]