Cdk5 and the mystery of synaptic vesicle endocytosis

doi:10.1083/jcb.200310038

Published 24 November 2003. doi:10.1083/jcb.200310038

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© The Rockefeller University Press, 0021-9525/2003/11/697 $8.00
The Journal of Cell Biology, Volume 163, Number 4, 697-699

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Cdk5 and the mystery of synaptic vesicle endocytosis

Chan Nguyen and James A. Bibb

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 74390

Address correspondence to James A. Bibb, Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., NC5.410, Dallas, TX 75390-9070. Tel.: (214) 648-4168. Fax: (214) 648-1293. email: james.bibb{at}utsouthwestern.edu

Regulation of endocytosis by protein phosphorylation and dephosphorylationis critical to synaptic vesicle recycling. Two groups have nowidentified the neuronal kinase Cdk5 (cyclin-dependent kinase5) as an important regulator of this process. Robinson and coworkersrecently demonstrated that Cdk5 is necessary for synaptic vesicleendocytosis (SVE) (Tan et al., 2003), whereas a new report inthis issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003).Careful examination of the data reveals a modelthat helps resolve the apparently contradictory nature of thesereports.

Abbreviation used in this paper: SVE, synaptic vesicle endocytosis.

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