VEGF is a chemoattractant for FGF-2-stimulated neural progenitors

doi:10.1083/jcb.200308040

Published 22 December 2003. doi:10.1083/jcb.200308040

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© The Rockefeller University Press, 0021-9525/2003/12/1375 $8.00
The Journal of Cell Biology, Volume 163, Number 6, 1375-1384

Article

VEGF is a chemoattractant for FGF-2–stimulated neural progenitors

Huanxiang Zhang¹, Laszlo Vutskits¹^,2, Michael S. Pepper¹ and Jozsef Z. Kiss¹

¹ Department of Morphology, University Medical Center, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland
² Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Hospital of Geneva, CH-1211 Geneva, Switzerland

Address correspondence to J.Z. Kiss, Dept. of Morphology, University Medical Center, University of Geneva Medical School, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland. Tel.: 41-22-3795202. Fax: 41-22-3795260. email: Jozsef.Kiss{at}medecine.unige.ch

Mmigration of undifferentiated neural progenitors is criticalfor the development and repair of the nervous system. However,the mechanisms and factors that regulate migration are not wellunderstood. Here, we show that vascular endothelial growth factor(VEGF)-A, a major angiogenic factor, guides the directed migrationof neural progenitors that do not display antigenic markersfor neuron- or glia-restricted precursor cells. We demonstratethat progenitor cells express both VEGF receptor (VEGFR) 1 andVEGFR2, but signaling through VEGFR2 specifically mediates thechemotactic effect of VEGF. The expression of VEGFRs and thechemotaxis of progenitors in response to VEGF require the presenceof fibroblast growth factor 2. These results demonstrate thatVEGF is an attractive guidance cue for the migration of undifferentiatedneural progenitors and offer a mechanistic link between neurogenesisand angiogenesis in the nervous system.

Key Words: VEGF receptors; live cell microscopy; directional guidance; cell motility; FGF-2

Abbreviations used in this paper: FMI, forward migration index;SVZ, subventricular zone; VEGFR, VEGF receptor.

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