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Cleavage furrow positioning

Research Institute of Molecular Pathology, A-1030 Vienna, Austria

Address correspondence to Michael Glotzer, Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. Tel.: 43-1-797-30-525. Fax: 43-1-798-7153. email: mglotzer{at}imp.univie.ac.at

To complete the cell cycle, the cleavage furrow draws the plasma membrane toward the cell center, pinching the cytoplasm into two lobes that are subsequently separated into two cells. The position of the cleavage furrow is induced by the mitotic spindle during early anaphase. Although the mechanism of cleavage furrow positioning is not understood at a molecular level, recent results suggest that it might be mediated by local relief from the inhibitory effects of microtubules.

Key Words: cytokinesis; Rho; microtubule; kinesin; actin

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