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Published online 26 January 2004. doi:10.1083/jcb.200307048
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 164, Number 3, 417-426
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Article

WASp is required for the correct temporal morphogenesis of rhabdomere microvilli



Andrew C. Zelhof and Robert W. Hardy

Division of Biology, University of California, San Diego, La Jolla, CA 92093

Address correspondence to Andrew C. Zelhof, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0649. Tel.: (858) 534-5423. Fax: (858) 534-8510. email: azelhof{at}biomail.ucsd.edu

Microvilli are actin-based fingerlike membrane projections that form the basis of the brush border of enterocytes and the Drosophila melanogaster photoreceptor rhabdomere. Although many microvillar cytoskeletal components have been identified, the molecular basis of microvillus formation is largely undefined. Here, we report that the Wiskott-Aldrich syndrome protein (WASp) is necessary for rhabdomere microvillus morphogenesis. We show that WASp accumulates on the photoreceptor apical surface before microvillus formation, and at the time of microvillus initiation WASp colocalizes with amphiphysin and moesin. The loss of WASp delays the enrichment of F-actin on the apical photoreceptor surface, delays the appearance of the primordial microvillar projections, and subsequently leads to malformed rhabdomeres.

Key Words: chaoptin; photoreceptor; Drosophila; amphiphysin; moesin

Abbreviations used in this paper: Amph, amphiphysin; APF, after puparium formation; Mtl, Mig2-like; PAK, p21-activated kinase; PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate; WASp, Wiskott-Aldrich syndrome protein.


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