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A correction to this article has been published: Titorenko and Rachubinski, J. Cell Biol. 165 (1) 155
Published online 23 February 2004. doi:10.1083/jcb.200312081
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 164, Number 5, 641-645
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Mini-Review

The peroxisome

: orchestrating important developmental decisions from inside the cell



Vladimir I. Titorenko1 and Richard A. Rachubinski2

1 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada
2 Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada

Address correspondence to Vladimir I. Titorenko, Department of Biology, Concordia University, 7141 Sherbrooke St., West SP Building, Room SP-501-9, Montreal, Quebec H4B 1R6, Canada. Tel.: (514) 848-2424, ext. 3424. Fax: (514) 848-2881. email: VTITOR{at}vax2.concordia.ca; or Richard A. Rachubinski, Department of Cell Biology, University of Alberta, Medical Sciences Building 5-14, Edmonton, Alberta T6G 2H7, Canada. Tel.: (780) 492-9868. Fax: (780) 492-9278. email: rick.rachubinski{at}ualberta.ca

The peroxisome has long been known for its role in lipid metabolism and hydrogen peroxide detoxification. However, growing evidence supports the view that this organelle can also function both as an intracellular signaling compartment and as an organizing platform that orchestrates certain developmental decisions from inside the cell. This review highlights various strategies that peroxisomes employ to regulate the processes of development, differentiation, and morphogenesis and critically evaluates several molecular mechanisms by which peroxisomes promote these processes.

Abbreviations used in this paper: ABC, ATP-binding cassette; HIV, human immunodeficiency virus; PBD, peroxisome biogenesis disorder; PTS, peroxisomal targeting signal; ROS, reactive oxygen species; RV, rotavirus.


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