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Takako Sasaki¹, Reinhard Fässler¹, and Erhard Hohenester²

¹ Department of Molecular Medicine, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany
² Department of Biological Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK

Address correspondence to Erhard Hohenester, Department of Biological Sciences, Biophysics Group, Blackett Laboratory, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Tel.: 44-20-7594-7701. Fax: 44-20-7589-0191. email: e.hohenester{at}imperial.ac.uk

Laminin-1 is emerging as the key molecule in early embryonic basement membrane assembly. Here we review recent insights into its functions gained from the synergistic application of genetic and structural methods.

Key Words: extracellular matrix; embryo development; mutagenesis; structure determination

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