Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 2105K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hitomi, J. Articles by Tohyama, M. Search for Related Content PubMed PubMed Citation Articles by Hitomi, J. Articles by Tohyama, M. Related Collections Related Article Social Bookmarking                            What's this?

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aß-induced cell death

¹ Department of Anatomy and Neuroscience, Department of Post-Genomics and Diseases, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
² Division of Molecular Genetics, Department of Post-Genomics and Diseases, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
³ Division of Psychiatry and Behavioural Proteomics, Department of Post-Genomics and Diseases, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
⁴ Department of Anatomy, Asahikawa Medical College, Midorigaoka Higashi, Asahikawa, Hokkaido, 078-8510, Japan
⁵ Division of Structural Cell Biology, Nara Institute of Science and Technology, Takayama, Ikoma, Nara 630-0101, Japan
⁶ 21st Century COE Program, Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-8471, Japan
⁷ Solution Oriented Research for Science and Technology of Japan, Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama, 332-0012, Japan

Address correspondence to Taiichi Katayama, Dept. of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. Tel.: 81-6-6879-3221. Fax: 81-6-6879-3229. email: katayama{at}anat2.med.osaka-u.ac.jp; or Yutaka Eguchi, Division of Molecular Genetics, Dept. of Post-Genomics and Disease, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan. Tel.: 81-6-6879-3363. Fax: 81-6-6879-3369. email: eguchi{at}gene.med.osaka-u.ac.jp

Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been implicated in ER stress-induced apoptosis and amyloid-ß (Aß)–induced apoptosis in rodents, it is controversial whether similar mechanisms operate in humans. We found that human caspase-4, a member of caspase-1 subfamily that includes caspase-12, is localized to the ER membrane, and is cleaved when cells are treated with ER stress-inducing reagents, but not with other apoptotic reagents. Cleavage of caspase-4 is not affected by overexpression of Bcl-2, which prevents signal transduction on the mitochondria, suggesting that caspase-4 is primarily activated in ER stress-induced apoptosis. Furthermore, a reduction of caspase-4 expression by small interfering RNA decreases ER stress-induced apoptosis in some cell lines, but not other ER stress-independent apoptosis. Caspase-4 is also cleaved by administration of Aß, and Aß-induced apoptosis is reduced by small interfering RNAs to caspase-4. Thus, caspase-4 can function as an ER stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease.

Key Words: apoptosis; ER stress; caspase-4; Alzheimer's disease; amyloid-ß

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

Related Article

A caspase for stress

William A. Wells
J. Cell Biol. 2004 165: 295. [Full Text] [PDF]

This article has been cited by other articles:

• Lin, Y.-F., Tsai, W.-P., Liu, H.-G., Liang, P.-H. (2009). Intracellular {beta}-Tubulin/Chaperonin Containing TCP1-{beta} Complex Serves as a Novel Chemotherapeutic Target against Drug-Resistant Tumors. Cancer Res. 69: 6879-6888 [Abstract] [Full Text]  
• Dantuma, N. P., Lindsten, K. (2009). Stressing the ubiquitin/proteasome system. Cardiovasc Res 0: cvp255v2-cvp255 [Abstract] [Full Text]  
• Ghavami, S, Hashemi, M, Ande, S R, Yeganeh, B, Xiao, W, Eshraghi, M, Bus, C J, Kadkhoda, K, Wiechec, E, Halayko, A J, Los, M (2009). Apoptosis and cancer: mutations within caspase genes. J. Med. Genet. 46: 497-510 [Abstract] [Full Text]  
• Matsuura, G., Morinaga, N., Yahiro, K., Komine, R., Moss, J., Yoshida, H., Noda, M. (2009). Novel Subtilase Cytotoxin Produced by Shiga-Toxigenic Escherichia coli Induces Apoptosis in Vero Cells via Mitochondrial Membrane Damage. Infect. Immun. 77: 2919-2924 [Abstract] [Full Text]  
• AKAMATSU, K., SHIBATA, M.-A., ITO, Y., SOHMA, Y., AZUMA, H., OTSUKI, Y. (2009). Riluzole Induces Apoptotic Cell Death in Human Prostate Cancer Cells via Endoplasmic Reticulum Stress. Anticancer Res 29: 2195-2204 [Abstract] [Full Text]  
• Nishitsuji, K., Tomiyama, T., Ishibashi, K., Ito, K., Teraoka, R., Lambert, M. P., Klein, W. L., Mori, H. (2009). The E693{Delta} Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid {beta} Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells. Am. J. Pathol. 174: 957-969 [Abstract] [Full Text]  
• Jiang, C. C., Mao, Z. G., Avery-Kiejda, K. A., Wade, M., Hersey, P., Zhang, X. D. (2009). Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis 30: 197-204 [Abstract] [Full Text]  
• Fels, D. R., Ye, J., Segan, A. T., Kridel, S. J., Spiotto, M., Olson, M., Koong, A. C., Koumenis, C. (2008). Preferential Cytotoxicity of Bortezomib toward Hypoxic Tumor Cells via Overactivation of Endoplasmic Reticulum Stress Pathways. Cancer Res. 68: 9323-9330 [Abstract] [Full Text]  
• Kim, J., Choi, T. G., Ding, Y., Kim, Y., Ha, K. S., Lee, K. H., Kang, I., Ha, J., Kaufman, R. J., Lee, J., Choe, W., Kim, S. S. (2008). Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J. Cell Sci. 121: 3636-3648 [Abstract] [Full Text]  
• Korfei, M., Ruppert, C., Mahavadi, P., Henneke, I., Markart, P., Koch, M., Lang, G., Fink, L., Bohle, R.-M., Seeger, W., Weaver, T. E., Guenther, A. (2008). Epithelial Endoplasmic Reticulum Stress and Apoptosis in Sporadic Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 178: 838-846 [Abstract] [Full Text]  
• Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J., McConkey, D. J. (2008). Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood 112: 2917-2926 [Abstract] [Full Text]  
• Song, S., Lee, H., Kam, T.-I., Tai, M. L., Lee, J.-Y., Noh, J.-Y., Shim, S. M., Seo, S. J., Kong, Y.-Y., Nakagawa, T., Chung, C.-W., Choi, D.-Y., Oubrahim, H., Jung, Y.-K. (2008). E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated A{beta} neurotoxicity. JCB 182: 675-684 [Abstract] [Full Text]  
• Jiang, C. C., Lucas, K., Avery-Kiejda, K. A., Wade, M., deBock, C. E., Thorne, R. F., Allen, J., Hersey, P., Zhang, X. D. (2008). Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress. Cancer Res. 68: 6708-6717 [Abstract] [Full Text]  
• Yung, H.-w., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., Burton, G. J. (2008). Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction. Am. J. Pathol. 173: 451-462 [Abstract] [Full Text]  
• Upton, J.-P., Austgen, K., Nishino, M., Coakley, K. M., Hagen, A., Han, D., Papa, F. R., Oakes, S. A. (2008). Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress. Mol. Cell. Biol. 28: 3943-3951 [Abstract] [Full Text]  
• Koyama, Y., Matsuzaki, S., Gomi, F., Yamada, K., Katayama, T., Sato, K., Kumada, T., Fukuda, A., Matsuda, S., Tano, Y., Tohyama, M. (2008). Induction of Amyloid {beta} Accumulation by ER Calcium Disruption and Resultant Upregulation of Angiogenic Factors in ARPE19 Cells. IOVS 49: 2376-2383 [Abstract] [Full Text]  
• Ou, L., Wu, Y., Ip, C., Meng, X., Hsu, Y.-C., Ip, M. M. (2008). Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. J. Lipid Res. 49: 985-994 [Abstract] [Full Text]  
• Haataja, L., Gurlo, T., Huang, C. J., Butler, P. C. (2008). Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis. Endocr. Rev. 29: 303-316 [Abstract] [Full Text]  
• Zhang, G., Dong, Y., Zhang, B., Ichinose, F., Wu, X., Culley, D. J., Crosby, G., Tanzi, R. E., Xie, Z. (2008). Isoflurane-Induced Caspase-3 Activation Is Dependent on Cytosolic Calcium and Can Be Attenuated by Memantine. J. Neurosci. 28: 4551-4560 [Abstract] [Full Text]  
• Park, M. A., Yacoub, A., Rahmani, M., Zhang, G., Hart, L., Hagan, M. P., Calderwood, S. K., Sherman, M. Y., Koumenis, C., Spiegel, S., Chen, C.-S., Graf, M., Curiel, D. T., Fisher, P. B., Grant, S., Dent, P. (2008). OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells. Mol. Pharmacol. 73: 1168-1184 [Abstract] [Full Text]  
• Chen, L. H., Jiang, C. C., Watts, R., Thorne, R. F., Kiejda, K. A., Zhang, X. D., Hersey, P. (2008). Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis of Melanoma Cells by the ARC Protein. Cancer Res. 68: 834-842 [Abstract] [Full Text]  
• Kardosh, A., Golden, E. B., Pyrko, P., Uddin, J., Hofman, F. M., Chen, T. C., Louie, S. G., Petasis, N. A., Schonthal, A. H. (2008). Aggravated Endoplasmic Reticulum Stress as a Basis for Enhanced Glioblastoma Cell Killing by Bortezomib in Combination with Celecoxib or Its Non-Coxib Analogue, 2,5-Dimethyl-Celecoxib. Cancer Res. 68: 843-851 [Abstract] [Full Text]  
• Yacoub, A., Park, M. A., Gupta, P., Rahmani, M., Zhang, G., Hamed, H., Hanna, D., Sarkar, D., Lebedeva, I. V., Emdad, L., Sauane, M., Vozhilla, N., Spiegel, S., Koumenis, C., Graf, M., Curiel, D. T., Grant, S., Fisher, P. B., Dent, P. (2008). Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cells. Molecular Cancer Therapeutics 7: 297-313 [Abstract] [Full Text]  
• Huang, D., Cai, D. T., Chua, R. Y. R., Kemeny, D. M., Wong, S. H. (2008). Nitric-oxide Synthase 2 Interacts with CD74 and Inhibits Its Cleavage by Caspase during Dendritic Cell Development. J. Biol. Chem. 283: 1713-1722 [Abstract] [Full Text]  
• Lin, F.-R., Kuo, H.-K., Ying, H.-Y., Yang, F.-H., Lin, K.-I (2007). Induction of Apoptosis in Plasma Cells by B Lymphocyte Induced Maturation Protein-1 Knockdown. Cancer Res. 67: 11914-11923 [Abstract] [Full Text]  
• Lakshmanan, U., Porter, A. G. (2007). Caspase-4 Interacts with TNF Receptor-Associated Factor 6 and Mediates Lipopolysaccharide-Induced NF-{kappa}B-Dependent Production of IL-8 and CC Chemokine Ligand 4 (Macrophage-Inflammatory Protein-1 ). J. Immunol. 179: 8480-8490 [Abstract] [Full Text]  
• Pyrko, P., Kardosh, A., Wang, W., Xiong, W., Schonthal, A. H., Chen, T. C. (2007). HIV-1 Protease Inhibitors Nelfinavir and Atazanavir Induce Malignant Glioma Death by Triggering Endoplasmic Reticulum Stress. Cancer Res. 67: 10920-10928 [Abstract] [Full Text]  
• Nieto-Miguel, T., Fonteriz, R. I., Vay, L., Gajate, C., Lopez-Hernandez, S., Mollinedo, F. (2007). Endoplasmic Reticulum Stress in the Proapoptotic Action of Edelfosine in Solid Tumor Cells. Cancer Res. 67: 10368-10378 [Abstract] [Full Text]  
• Scherbik, S. V., Stockman, B. M., Brinton, M. A. (2007). Differential Expression of Interferon (IFN) Regulatory Factors and IFN-Stimulated Genes at Early Times after West Nile Virus Infection of Mouse Embryo Fibroblasts. J. Virol. 81: 12005-12018 [Abstract] [Full Text]  
• Chen, L. H., Jiang, C. C., Kiejda, K. A., Wang, Y. F., Thorne, R. F., Zhang, X. D., Hersey, P. (2007). Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response. Carcinogenesis 28: 2328-2336 [Abstract] [Full Text]  
• Jiang, C. C., Chen, L. H., Gillespie, S., Wang, Y. F., Kiejda, K. A., Zhang, X. D., Hersey, P. (2007). Inhibition of MEK Sensitizes Human Melanoma Cells to Endoplasmic Reticulum Stress-Induced Apoptosis. Cancer Res. 67: 9750-9761 [Abstract] [Full Text]  
• Endo, H., Murata, K., Mukai, M., Ishikawa, O., Inoue, M. (2007). Activation of Insulin-like Growth Factor Signaling Induces Apoptotic Cell Death Under Prolonged Hypoxia by Enhancing Endoplasmic Reticulum Stress Response. Cancer Res. 67: 8095-8103 [Abstract] [Full Text]  
• Mulugeta, S., Maguire, J. A., Newitt, J. L., Russo, S. J., Kotorashvili, A., Beers, M. F. (2007). Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L720-L729 [Abstract] [Full Text]  
• Rahmani, M., Davis, E. M., Crabtree, T. R., Habibi, J. R., Nguyen, T. K., Dent, P., Grant, S. (2007). The Kinase Inhibitor Sorafenib Induces Cell Death through a Process Involving Induction of Endoplasmic Reticulum Stress. Mol. Cell. Biol. 27: 5499-5513 [Abstract] [Full Text]  
• Huang, C.-j., Lin, C.-y., Haataja, L., Gurlo, T., Butler, A. E., Rizza, R. A., Butler, P. C. (2007). High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress Mediated {beta}-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes. Diabetes 56: 2016-2027 [Abstract] [Full Text]  
• Lai, E., Teodoro, T., Volchuk, A. (2007). Endoplasmic Reticulum Stress: Signaling the Unfolded Protein Response. Physiology 22: 193-201 [Abstract] [Full Text]  
• Hsu, M.-J., Hsu, C. Y., Chen, B.-C., Chen, M.-C., Ou, G., Lin, C.-H. (2007). Apoptosis Signal-Regulating Kinase 1 in Amyloid {beta} Peptide-Induced Cerebral Endothelial Cell Apoptosis. J. Neurosci. 27: 5719-5729 [Abstract] [Full Text]  
• Colla, S., Zhan, F., Xiong, W., Wu, X., Xu, H., Stephens, O., Yaccoby, S., Epstein, J., Barlogie, B., Shaughnessy, J. D. Jr (2007). The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood 109: 4470-4477 [Abstract] [Full Text]  
• Pyrko, P., Kardosh, A., Liu, Y.-T., Soriano, N., Xiong, W., Chow, R. H., Uddin, J., Petasis, N. A., Mircheff, A. K., Farley, R. A., Louie, S. G., Chen, T. C., Schonthal, A. H. (2007). Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Molecular Cancer Therapeutics 6: 1262-1275 [Abstract] [Full Text]  
• Murakami, Y., Aizu-Yokota, E., Sonoda, Y., Ohta, S., Kasahara, T. (2007). Suppression of Endoplasmic Reticulum Stress-induced Caspase Activation and Cell Death by the Overexpression of Bcl-xL or Bcl-2. J Biochem 141: 401-410 [Abstract] [Full Text]  
• Rebe, C., Cathelin, S., Launay, S., Filomenko, R., Prevotat, L., L'Ollivier, C., Gyan, E., Micheau, O., Grant, S., Dubart-Kupperschmitt, A., Fontenay, M., Solary, E. (2007). Caspase-8 prevents sustained activation of NF-{kappa}B in monocytes undergoing macrophagic differentiation. Blood 109: 1442-1450 [Abstract] [Full Text]  
• Kanan, Y., Moiseyev, G., Agarwal, N., Ma, J.-X., Al-Ubaidi, M. R. (2007). Light Induces Programmed Cell Death by Activating Multiple Independent Proteases in a Cone Photoreceptor Cell Line. IOVS 48: 40-51 [Abstract] [Full Text]  
• Kumar, S., Kasseckert, S., Kostin, S., Abdallah, Y., Schafer, C., Kaminski, A., Reusch, H. P., Piper, H. M., Steinhoff, G., Ladilov, Y. (2007). Ischemic acidosis causes apoptosis in coronary endothelial cells through activation of caspase-12. Cardiovasc Res 73: 172-180 [Abstract] [Full Text]  
• Lopez-Anton, N., Rudy, A., Barth, N., Schmitz, L. M., Pettit, G. R., Schulze-Osthoff, K., Dirsch, V. M., Vollmar, A. M. (2006). The Marine Product Cephalostatin 1 Activates an Endoplasmic Reticulum Stress-specific and Apoptosome-independent Apoptotic Signaling Pathway. J. Biol. Chem. 281: 33078-33086 [Abstract] [Full Text]  
• Nadiri, A., Wolinski, M. K., Saleh, M. (2006). The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis. J. Immunol. 177: 4239-4245 [Abstract] [Full Text]  
• Shiraishi, H., Okamoto, H., Yoshimura, A., Yoshida, H. (2006). ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. J. Cell Sci. 119: 3958-3966 [Abstract] [Full Text]  
• Milleron, R. S., Bratton, S. B. (2006). Heat Shock Induces Apoptosis Independently of Any Known Initiator Caspase-activating Complex. J. Biol. Chem. 281: 16991-17000 [Abstract] [Full Text]  
• Tan, Y., Dourdin, N., Wu, C., De Veyra, T., Elce, J. S., Greer, P. A. (2006). Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis. J. Biol. Chem. 281: 16016-16024 [Abstract] [Full Text]  
• Kim, S.-J., Zhang, Z., Hitomi, E., Lee, Y.-C., Mukherjee, A. B. (2006). Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL. Hum Mol Genet 15: 1826-1834 [Abstract] [Full Text]  
• Kim, S.-J., Zhang, Z., Lee, Y.-C., Mukherjee, A. B. (2006). Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL. Hum Mol Genet 15: 1580-1586 [Abstract] [Full Text]  
• Hu, P., Han, Z., Couvillon, A. D., Kaufman, R. J., Exton, J. H. (2006). Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1{alpha}-Mediated NF-{kappa}B Activation and Down-Regulation of TRAF2 Expression. Mol. Cell. Biol. 26: 3071-3084 [Abstract] [Full Text]  
• Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H.I., Dunner, K. Jr., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., Xiong, H., Abbruzzese, J. L., McConkey, D. J. (2006). Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.. Cancer Res. 66: 3773-3781 [Abstract] [Full Text]  
• Su, Z., Kuball, J., Barreiros, A.-P., Gottfried, D., Ferreira, E. A., Theobald, M., Galle, P. R., Strand, D., Strand, S. (2006). Nitric Oxide Promotes Resistance to Tumor Suppression by CTLs. J. Immunol. 176: 3923-3930 [Abstract] [Full Text]  
• Li, J., Lee, B., Lee, A. S. (2006). Endoplasmic Reticulum Stress-induced Apoptosis: MULTIPLE PATHWAYS AND ACTIVATION OF p53-UP-REGULATED MODULATOR OF APOPTOSIS (PUMA) AND NOXA BY p53. J. Biol. Chem. 281: 7260-7270 [Abstract] [Full Text]  
• Pelletier, N., Casamayor-Palleja, M., De Luca, K., Mondiere, P., Saltel, F., Jurdic, P., Bella, C., Genestier, L., Defrance, T. (2006). The Endoplasmic Reticulum Is a Key Component of the Plasma Cell Death Pathway. J. Immunol. 176: 1340-1347 [Abstract] [Full Text]  
• Bridges, J. P., Xu, Y., Na, C.-L., Wong, H. R., Weaver, T. E. (2006). Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C. JCB 172: 395-407 [Abstract] [Full Text]  
• Nawrocki, S. T., Carew, J. S., Dunner, K. Jr., Boise, L. H., Chiao, P. J., Huang, P., Abbruzzese, J. L., McConkey, D. J. (2005). Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells. Cancer Res. 65: 11510-11519 [Abstract] [Full Text]  
• Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Dunner, K. Jr., Huang, P., Abbruzzese, J. L., McConkey, D. J. (2005). Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis. Cancer Res. 65: 11658-11666 [Abstract] [Full Text]  
• Gray, M. D., Mann, M., Nitiss, J. L., Hendershot, L. M. (2005). Activation of the Unfolded Protein Response Is Necessary and Sufficient for Reducing Topoisomerase II{alpha} Protein Levels and Decreasing Sensitivity to Topoisomerase-Targeted Drugs. Mol. Pharmacol. 68: 1699-1707 [Abstract] [Full Text]  
• Hidvegi, T., Schmidt, B. Z., Hale, P., Perlmutter, D. H. (2005). Accumulation of Mutant {alpha}1-Antitrypsin Z in the Endoplasmic Reticulum Activates Caspases-4 and -12, NF{kappa}B, and BAP31 but Not the Unfolded Protein Response. J. Biol. Chem. 280: 39002-39015 [Abstract] [Full Text]  
• Menendez-Benito, V., Verhoef, L. G.G.C., Masucci, M. G., Dantuma, N. P. (2005). Endoplasmic reticulum stress compromises the ubiquitin-proteasome system. Hum Mol Genet 14: 2787-2799 [Abstract] [Full Text]  
• Yang, X., Wang, J., Liu, C., Grizzle, W. E., Yu, S., Zhang, S., Barnes, S., Koopman, W. J., Mountz, J. D., Kimberly, R. P., Zhang, H.-G. (2005). Cleavage of p53-Vimentin Complex Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts. Am. J. Pathol. 167: 705-719 [Abstract] [Full Text]  
• Obeng, E. A., Boise, L. H. (2005). Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis. J. Biol. Chem. 280: 29578-29587 [Abstract] [Full Text]  
• Liu, H., Baliga, R. (2005). Endoplasmic Reticulum Stress-Associated Caspase 12 Mediates Cisplatin-Induced LLC-PK1 Cell Apoptosis. J. Am. Soc. Nephrol. 16: 1985-1992 [Abstract] [Full Text]  
• Lucken-Ardjomande, S., Martinou, J.-C. (2005). Newcomers in the process of mitochondrial permeabilization. J. Cell Sci. 118: 473-483 [Abstract] [Full Text]  
• Hu, P., Han, Z., Couvillon, A. D., Exton, J. H. (2004). Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death. J. Biol. Chem. 279: 49420-49429 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents