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Michael D. Schaller

Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599

Address correspondence to Michael D. Schaller, Dept. of Cell and Developmental Biology, 534 Taylor Hall, CB #7090, University of North Carolina, Chapel Hill, NC 27599. Tel.: (919) 966-0391. Fax: (919) 966-1856. email: crispy4{at}med.unc.edu

Abstract
FAK and paxillin are important components in integrin-regulated signaling. New evidence suggests that these two proteins function in crosstalk between cell–matrix and cell–cell adhesions. Further, new insight suggests that under some conditions these proteins inhibit cell migration, in contrast to their established roles in several cell systems as positive regulators of cell adhesion and migration.

Abbreviation used in this paper: siRNA, small interfering RNA.

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