JCB logo
Accuri Cytometers
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 16 August 2004. doi:10.1083/jcb.200405110
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 166, Number 4, 447-453
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 2499K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Imanishi, Y.
Right arrow Articles by Palczewski, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Imanishi, Y.
Right arrow Articles by Palczewski, K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Mini-Review

Retinosomes

: new insights into intracellular managing of hydrophobic substances in lipid bodies



Yoshikazu Imanishi1, Volker Gerke4, and Krzysztof Palczewski1,2,3

1 Department of Ophthalmology, University of Washington, Seattle, WA 98195
2 Department of Pharmacology, University of Washington, Seattle, WA 98195
3 Department of Chemistry, University of Washington, Seattle, WA 98195
4 Institute for Medical Biochemistry, University of Münster, 48149 Münster, Germany

Address correspondence to Krzysztof Palczewski, Dept. of Ophthalmology, University of Washington, Box 356485, Seattle, WA 98195-6485. Tel.: (206) 543-9074. Fax: (206) 221-6784. email: palczews{at}u.washington.edu


Abstract

Lipid bodies form autonomous intracellular structures in many model cells and in some cells of specific tissue origin. They contain hydrophobic substances, a set of structural proteins such as perilipin or adipose differentiation-related protein, enzymes implicated in lipid metabolism, and proteins that participate in signaling and membrane trafficking. Retinosomes, particles reminiscent of lipid bodies, have been identified in retinal pigment epithelium as distinct structures compartmentalizing a metabolic intermediate involved in regeneration of the visual chromophore. These observations suggest that lipid bodies, including retinosomes, carry out specific functions that go beyond those of mere lipid storage organelles.

Key Words: retinoid cycle; retina; lipid body; retinal pigment epithelium; adipose differentiation-related protein

Abbreviations used in this paper: ADRP, adipose differentiation-related protein; LRAT, lecithin retinol acyltransferase; RPE, retinal pigment epithelium.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents