Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1204K) PPT slides of all figures Correction (v169,p987) Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bompard, G. Articles by Caron, E. Search for Related Content PubMed PubMed Citation Articles by Bompard, G. Articles by Caron, E. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                      What's this?

Guillaume Bompard¹ and Emmanuelle Caron²

¹ School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK
² Centre for Molecular Microbiology and Infection and Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK

Address correspondence to Guillaume Bompard, School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK. Tel.: 44-121-414-2508. Fax: 44-121-414-5925. email: G.Bompard{at}bham.ac.uk

Abstract
Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.

Abbreviations used in this paper: Abi, Abl interactor; GBD, GTPase binding domain; Nap1, Nck-associated protein; PIR121, p53 inducible messenger RNA; SCAR, suppressor of cAMP receptor; WASP, WAVE, WASP family verprolin homologous; Wiskott-Aldrich syndrome protein; WHD, WASP homology domain.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Lammers, M., Meyer, S., Kuhlmann, D., Wittinghofer, A. (2008). Specificity of Interactions between mDia Isoforms and Rho Proteins. J. Biol. Chem. 283: 35236-35246 [Abstract] [Full Text]  
• Syriani, E., Gomez-Cabrero, A., Bosch, M., Moya, A., Abad, E., Gual, A., Gasull, X., Morales, M. (2008). Profilin induces lamellipodia by growth factor-independent mechanism. FASEB J. 22: 1581-1596 [Abstract] [Full Text]  
• Danson, C. M., Pocha, S. M., Bloomberg, G. B., Cory, G. O. (2007). Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. J. Cell Sci. 120: 4144-4154 [Abstract] [Full Text]  
• Eto, K., Nishikii, H., Ogaeri, T., Suetsugu, S., Kamiya, A., Kobayashi, T., Yamazaki, D., Oda, A., Takenawa, T., Nakauchi, H. (2007). The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110: 3637-3647 [Abstract] [Full Text]  
• Bosse, T., Ehinger, J., Czuchra, A., Benesch, S., Steffen, A., Wu, X., Schloen, K., Niemann, H. H., Scita, G., Stradal, T. E. B., Brakebusch, C., Rottner, K. (2007). Cdc42 and Phosphoinositide 3-Kinase Drive Rac-Mediated Actin Polymerization Downstream of c-Met in Distinct and Common Pathways. Mol. Cell. Biol. 27: 6615-6628 [Abstract] [Full Text]  
• Sossey-Alaoui, K., Li, X., Cowell, J. K. (2007). c-Abl-mediated Phosphorylation of WAVE3 Is Required for Lamellipodia Formation and Cell Migration. J. Biol. Chem. 282: 26257-26265 [Abstract] [Full Text]  
• Yip, S.-C., El-Sibai, M., Coniglio, S. J., Mouneimne, G., Eddy, R. J., Drees, B. E., Neilsen, P. O., Goswami, S., Symons, M., Condeelis, J. S., Backer, J. M. (2007). The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. J. Cell Sci. 120: 3138-3146 [Abstract] [Full Text]  
• Vincent, C., Maridonneau-Parini, I., Le Clainche, C., Gounon, P., Labrousse, A. (2007). Activation of p61Hck Triggers WASp- and Arp2/3-dependent Actin-comet Tail Biogenesis and Accelerates Lysosomes. J. Biol. Chem. 282: 19565-19574 [Abstract] [Full Text]  
• Millard, T. H., Dawson, J., Machesky, L. M. (2007). Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. J. Cell Sci. 120: 1663-1672 [Abstract] [Full Text]  
• Caracino, D., Jones, C., Compton, M., Saxe, C. L. III (2007). The N-Terminus of Dictyostelium Scar Interacts with Abi and HSPC300 and Is Essential for Proper Regulation and Function. Mol. Biol. Cell 18: 1609-1620 [Abstract] [Full Text]  
• Li, Y., Clough, N., Sun, X., Yu, W., Abbott, B. L., Hogan, C. J., Dai, Z. (2007). Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway. J. Cell Sci. 120: 1436-1446 [Abstract] [Full Text]  
• Rueda, D., Gaide, O., Ho, L., Lewkowicz, E., Niedergang, F., Hailfinger, S., Rebeaud, F., Guzzardi, M., Conne, B., Thelen, M., Delon, J., Ferch, U., Mak, T. W., Ruland, J., Schwaller, J., Thome, M. (2007). Bcl10 Controls TCR- and Fc{gamma}R-Induced Actin Polymerization. J. Immunol. 178: 4373-4384 [Abstract] [Full Text]  
• Legg, J. A., Bompard, G., Dawson, J., Morris, H. L., Andrew, N., Cooper, L., Johnston, S. A., Tramountanis, G., Machesky, L. M. (2007). N-WASP Involvement in Dorsal Ruffle Formation in Mouse Embryonic Fibroblasts. Mol. Biol. Cell 18: 678-687 [Abstract] [Full Text]  
• Le Clainche, C., Schlaepfer, D., Ferrari, A., Klingauf, M., Grohmanova, K., Veligodskiy, A., Didry, D., Le, D., Egile, C., Carlier, M.-F., Kroschewski, R. (2007). IQGAP1 Stimulates Actin Assembly through the N-Wasp-Arp2/3 Pathway. J. Biol. Chem. 282: 426-435 [Abstract] [Full Text]  
• Ancliff, P. J., Blundell, M. P., Cory, G. O., Calle, Y., Worth, A., Kempski, H., Burns, S., Jones, G. E., Sinclair, J., Kinnon, C., Hann, I. M., Gale, R. E., Linch, D. C., Thrasher, A. J. (2006). Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia. Blood 108: 2182-2189 [Abstract] [Full Text]  
• Moseley, J. B., Goode, B. L. (2006). The Yeast Actin Cytoskeleton: from Cellular Function to Biochemical Mechanism. Microbiol. Mol. Biol. Rev. 70: 605-645 [Abstract] [Full Text]  
• Rakeman, A. S., Anderson, K. V. (2006). Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development 133: 3075-3083 [Abstract] [Full Text]  
• Kim, H.-J., DiBernardo, A. B., Sloane, J. A., Rasband, M. N., Solomon, D., Kosaras, B., Kwak, S. P., Vartanian, T. K. (2006). WAVE1 Is Required for Oligodendrocyte Morphogenesis and Normal CNS Myelination. J. Neurosci. 26: 5849-5859 [Abstract] [Full Text]  
• Mitsushima, M., Sezaki, T., Akahane, R., Ueda, K., Suetsugu, S., Takenawa, T., Kioka, N. (2006). Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. GENES CELLS 11: 281-292 [Abstract] [Full Text]  
• Kim, D. J., Kim, S. H., Lim, C. S., Choi, K. Y., Park, C. S., Sung, B. H., Yeo, M. G., Chang, S., Kim, J.-K., Song, W. K. (2006). Interaction of SPIN90 with the Arp2/3 Complex Mediates Lamellipodia and Actin Comet Tail Formation. J. Biol. Chem. 281: 617-625 [Abstract] [Full Text]  
• Bompard, G., Sharp, S. J., Freiss, G., Machesky, L. M. (2005). Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. J. Cell Sci. 118: 5393-5403 [Abstract] [Full Text]  
• Chereau, D., Kerff, F., Graceffa, P., Grabarek, Z., Langsetmo, K., Dominguez, R. (2005). Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. Proc. Natl. Acad. Sci. USA 102: 16644-16649 [Abstract] [Full Text]  
• Ingham, R. J., Colwill, K., Howard, C., Dettwiler, S., Lim, C. S. H., Yu, J., Hersi, K., Raaijmakers, J., Gish, G., Mbamalu, G., Taylor, L., Yeung, B., Vassilovski, G., Amin, M., Chen, F., Matskova, L., Winberg, G., Ernberg, I., Linding, R., O'Donnell, P., Starostine, A., Keller, W., Metalnikov, P., Stark, C., Pawson, T. (2005). WW Domains Provide a Platform for the Assembly of Multiprotein Networks. Mol. Cell. Biol. 25: 7092-7106 [Abstract] [Full Text]  
• Wasteneys, G. O., Yang, Z. (2004). New Views on the Plant Cytoskeleton. Plant Physiol. 136: 3884-3891 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents