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Published 25 October 2004. doi:10.1083/jcb.200409171
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 167, Number 2, 193-195
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Cell differentiation

: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins



Dan Lindholm1,2 and Urmas Arumäe3

1 Department of Neuroscience, Uppsala University, Biomedical Centre, S-751 23 Uppsala, Sweden
2 Minerva Research Institute, Biomedicum, FIN-00290 Helsinki, Finland
3 Institute of Biotechnology, University of Helsinki, FIN-00014 Helsinki, Finland

Correspondence to Dan Lindholm: Dan.Lindholm{at}neuro.uu.se


Abstract

The molecular mechanisms by which differentiated cells combat cell death and injury have remained unclear. In the current issue, it has been shown in neurons that cell differentiation is accompanied by a decrease in Apaf-1 and the activity of the apoptosome with an increased ability of the inhibitor of apoptosis proteins (IAPs) to sustain survival (Wright et al., 2004). These results, together with earlier ones, deepen our understanding of how cell death and the apoptosome are regulated during differentiation and in tumor cells.

Abbreviations used in this paper: AIP, Apaf-1 interacting protein; Apaf-1, apoptotic protease activating factor-1; BIR, baculovirus IAP repeat; CARD, caspase recruitment domain; IAP, inhibitor of apoptosis protein; XIAP, X chromosome–linked IAP.


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