Published 25 October 2004. doi:10.1083/jcb.200404181
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 167, Number 2, 209-213
The critical role of cyclin D2 in adult neurogenesis
Anna Kowalczyk1,2,
Robert K. Filipkowski1,
Marcin Rylski1,
Grzegorz M. Wilczynski1,3,
Filip A. Konopacki1,
Jacek Jaworski1,
Maria A. Ciemerych4,5,
Piotr Sicinski4,5, and
Leszek Kaczmarek1
1 Department of Molecular and Cellular Neurobiology, Nencki Institute, 02-093 Warsaw, Poland
2 Mossakowski Medical Research Centre, 02-106 Warsaw, Poland
3 Department of Pathology, Medical University of Warsaw, 02-106 Warsaw, Poland
4 Department of Cancer Biology, Dana-Farber Cancer Institute
5 Department of Pathology, Harvard Medical School, Boston, MA 02115
Correspondence to L. Kaczmarek: leszek{at}nencki.gov.pl
Abstract
Adult neurogenesis (i.e., proliferation and differentiation of neuronal precursors in the adult brain) is responsible for adding new neurons in the dentate gyrus of the hippocampus and in the olfactory bulb. We describe herein that adult mice mutated in the cell cycle regulatory gene Ccnd2, encoding cyclin D2, lack newly born neurons in both of these brain structures. In contrast, genetic ablation of cyclin D1 does not affect adult neurogenesis. Furthermore, we show that cyclin D2 is the only D-type cyclin (out of D1, D2, and D3) expressed in dividing cells derived from neuronal precursors present in the adult hippocampus. In contrast, all three cyclin D mRNAs are present in the cultures derived from 5-day-old hippocampi, when developmental neurogenesis in the dentate gyrus takes place. Thus, our results reveal the existence of molecular mechanisms discriminating adult versus developmental neurogeneses.
A. Kowalczyk and R.K. Filipkowski contributed equally to this paper.
M.A. Ciemerych's present address is Dept. of Embryology, Institute of Zoology, Warsaw University, 02-096 Warsaw, Poland.
Abbreviations used in this paper: DG, dentate gyrus; OB, olfactory bulb; SGZ, subgranular zone; WT, wild-type.
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