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Published 22 November 2004. doi:10.1083/jcb.200408061
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 167, Number 4, 613-625
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Article

Condensin restructures chromosomes in preparation for meiotic divisions



Raymond C. Chan, Aaron F. Severson, and Barbara J. Meyer

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720

Correspondence to Barbara J. Meyer: bjmeyer{at}uclink.berkeley.edu

The production of haploid gametes from diploid germ cells requires two rounds of meiotic chromosome segregation after one round of replication. Accurate meiotic chromosome segregation involves the remodeling of each pair of homologous chromosomes around the site of crossover into a highly condensed and ordered structure. We showed that condensin, the protein complex needed for mitotic chromosome compaction, restructures chromosomes during meiosis in Caenorhabditis elegans. In particular, condensin promotes both meiotic chromosome condensation after crossover recombination and the remodeling of sister chromatids. Condensin helps resolve cohesin-independent linkages between sister chromatids and alleviates recombination-independent linkages between homologues. The safeguarding of chromosome resolution by condensin permits chromosome segregation and is crucial for the formation of discrete, individualized bivalent chromosomes.

R.C. Chan and A.F. Severson contributed equally to this paper.

Abbreviations used in this paper: CAP, chromosome-associated polypeptide; DSB, double-strand break; HCP, holocentric chromosome-binding protein; IP, immunoprecipitation; NEBD, nuclear envelope breakdown; RNAi, RNA interference; SC, synaptonemal complex; SMC, structural maintenance of chromosomes.


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