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Going in GTP cycles in the nucleolus

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

Correspondence to Tom Misteli: mistelit{at}mail.nih.gov

Abstract

Proteins are directed to cellular compartments by specific localization signals. A GTP-driven cycle has now been identified as a mechanism for protein targeting to the nucleolus. The involvement of a GTP switch suggests that nucleolar localization can be regulated and may be responsive to extracellular stimuli via signaling pathways. The uncovered mechanism also implies that localization is determined by increased retention rather than directed targeting.

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