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Capacitative calcium entry

James W. Putney, Jr.

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health Department of Health and Human Services, Research Triangle Park, NC 27709

Correspondence to James W. Putney, Jr: putney{at}niehs.nih.gov

Abstract

A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule (STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.

Abbreviations used in this paper: CIF, calcium influx factor; IP₃, inositol 1,4,5-trisphosphate; SAM, sterile motif; STIM, stromal interaction molecule.

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