JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

doi:10.1083/jcb.17.2.375

This Article

	Full Text (PDF, 4869K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Farquhar, M. G.
	Articles by Palade, G. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Farquhar, M. G.
	Articles by Palade, G. E.

Social Bookmarking

	What's this?

ARTICLE

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Marilyn G. Farquhar Ph.D.¹ and George E. Palade M.D.¹

¹ From The Rockefeller Institute.

Dr. Farquhar's present address is Department of Pathology, University of California School of Medicine, San Francisco

The epithelia of a number of glands and cavitary organs ofthe rat and guinea pig have been surveyed, and in all casesinvestigated, a characteristic tripartite junctional complexhas been found between adjacent cells. Although the complexdiffers in precise arrangement from one organ to another, ithas been regularly encountered in the mucosal epithelia of thestomach, intestine, gall bladder, uterus, and oviduct; in theglandular epithelia of the liver, pancreas, parotid, stomach,and thyroid; in the epithelia of pancreatic, hepatic, and salivaryducts; and finally, between the epithelial cells of the nephron(proximal and distal convolution, collecting ducts). The elementsof the complex, identified as zonula occludens (tight junction),zonula adhaerens (intermediary junction), and macula adhaerens(desmosome), occupy a juxtaluminal position and succeed eachother in the order given in an apical-basal direction.

The zonulaoccludens (tight junction) is characterized by fusion of theadjacent cell membranes resulting in obliteration of the intercellularspace over variable distances. Within the obliterated zone,the dense outer leaflets of the adjoining cell membranes convergeto form a single intermediate line. A diffuse band of densecytoplasmic material is often associated with this junction,but its development varies from one epithelium to another.

Thezonula adhaerens (intermediate junction) is characterized bythe presence of an intercellular space ( $sim$ 200 A) occupied by homogeneous,apparently amorphous material of low density; by strict parallelismof the adjoining cell membranes over distances of 0.2 to 0.5µ; and by conspicuous bands of dense material located inthe subjacent cytoplasmic matrix.

The desmosome or macula adhaerensis also characterized by the presence of an intercellular space( $sim$ 240 A) which, in this case, contains a central disc of densematerial; by discrete cytoplasmic plaques disposed parallelto the inner leaflet of each cell membrane; and by the presenceof bundles of cytoplasmic fibrils converging on the plaques.

Thezonula occludens appears to form a continuous belt-like attachment,whereas the desmosome is a discontinuous, button-like structure.The zomula adhaerens is continuous in most epithelia but discontinuousin some. Observations made during experimental hemoglobinuriain rats showed that the hemoglobin, which undergoes enough concentrationin the nephron lumina to act as an electron-opaque mass tracer,does not penetrate the intercellular spaces beyond the zonulaoccludens. Similar observations were made in pancreatic aciniand ducts where discharged zymogen served as a mass tracer.Hence the tight junction is impervious to concentrated proteinsolutions and appears to function as a diffusion barrier or"seal." The desmosome and probably also the zonula adhaerensmay represent intercellular attachment devices.

Submitted on August 20, 1962

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Cypel, M., Liu, M., Rubacha, M., Yeung, J. C., Hirayama, S., Anraku, M., Sato, M., Medin, J., Davidson, B. L., de Perrot, M., Waddell, T. K., Slutsky, A. S., Keshavjee, S. (2009). Functional Repair of Human Donor Lungs by IL-10 Gene Therapy. Sci Transl Med 1: 4ra9-4ra9 [Abstract] [Full Text]
Mazzon, E., Crisafulli, C., Galuppo, M., Cuzzocrea, S. (2009). Role of peroxisome proliferator-activated receptor-{alpha} in ileum tight junction alteration in mouse model of restraint stress. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G488-G505 [Abstract] [Full Text]
Franke, W. W. (2009). Discovering the Molecular Components of Intercellular Junctions--A Historical View. Cold Spring Harb. Perspect. Biol. 1: a003061-a003061 [Abstract] [Full Text]
Anderson, J. M., Van Itallie, C. M. (2009). Physiology and Function of the Tight Junction. Cold Spring Harb. Perspect. Biol. 1: a002584-a002584 [Abstract] [Full Text]
Martini, S., Kretzler, M. (2009). How to Build a Tight but Permeable Glomerular Junction. J. Am. Soc. Nephrol. 20: 1420-1421 [Full Text]
Petecchia, L., Sabatini, F., Varesio, L., Camoirano, A., Usai, C., Pezzolo, A., Rossi, G. A. (2009). Bronchial Airway Epithelial Cell Damage Following Exposure to Cigarette Smoke Includes Disassembly of Tight Junction Components Mediated by the Extracellular Signal-Regulated Kinase 1/2 Pathway. Chest 135: 1502-1512 [Abstract] [Full Text]
Adachi, M., Hamazaki, Y., Kobayashi, Y., Itoh, M., Tsukita, S., Furuse, M., Tsukita, S. (2009). Similar and Distinct Properties of MUPP1 and Patj, Two Homologous PDZ Domain-Containing Tight-Junction Proteins. Mol. Cell. Biol. 29: 2372-2389 [Abstract] [Full Text]
Davuluri, G., Espina, V., Petricoin, E. F. III, Ross, M., Deng, J., Liotta, L. A., Glaser, B. M. (2009). Activated VEGF Receptor Shed Into the Vitreous in Eyes With Wet AMD: A New Class of Biomarkers in the Vitreous With Potential for Predicting the Treatment Timing and Monitoring Response. Arch Ophthalmol 127: 613-621 [Abstract] [Full Text]
Flynn, A. N., Itani, O. A., Moninger, T. O., Welsh, M. J. (2009). Acute regulation of tight junction ion selectivity in human airway epithelia. Proc. Natl. Acad. Sci. USA 106: 3591-3596 [Abstract] [Full Text]
Vagin, O., Kraut, J. A., Sachs, G. (2009). Role of N-glycosylation in trafficking of apical membrane proteins in epithelia. Am. J. Physiol. Renal Physiol. 296: F459-F469 [Abstract] [Full Text]
Liu, J. Y., Seno, H., Miletic, A. V., Mills, J. C., Swat, W., Stappenbeck, T. S. (2009). Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J. Cell Sci. 122: 324-334 [Abstract] [Full Text]
Lee, D. B. N., Jamgotchian, N., Allen, S. G., Abeles, M. B., Ward, H. J. (2008). A lipid-protein hybrid model for tight junction. Am. J. Physiol. Renal Physiol. 295: F1601-F1612 [Abstract] [Full Text]
Ikenouchi, J., Sasaki, H., Tsukita, S., Furuse, M., Tsukita, S. (2008). Loss of Occludin Affects Tricellular Localization of Tricellulin. Mol. Biol. Cell 19: 4687-4693 [Abstract] [Full Text]
Shen, L., Weber, C. R., Turner, J. R. (2008). The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. JCB 181: 683-695 [Abstract] [Full Text]
Oshima, T., Miwa, H., Joh, T. (2008). Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7. Am. J. Physiol. Cell Physiol. 295: C800-C806 [Abstract] [Full Text]
Kuramitsu, K., Ikeda, W., Inoue, N., Tamaru, Y., Takai, Y. (2008). Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain.. GENES CELLS 13: 797-805 [Abstract] [Full Text]
Kanzaki, N., Ogita, H., Komura, H., Ozaki, M., Sakamoto, Y., Majima, T., Ijuin, T., Takenawa, T., Takai, Y. (2008). Involvement of the nectin-afadin complex in PDGF-induced cell survival. J. Cell Sci. 121: 2008-2017 [Abstract] [Full Text]
Schumann, M, Richter, J F, Wedell, I, Moos, V, Zimmermann-Kordmann, M, Schneider, T, Daum, S, Zeitz, M, Fromm, M, Schulzke, J D (2008). Mechanisms of epithelial translocation of the {alpha}2-gliadin-33mer in coeliac sprue. Gut 57: 747-754 [Abstract] [Full Text]
Sun, J., Kintner, J., Schoborg, R. V. (2008). The host adherens junction molecule nectin-1 is downregulated in Chlamydia trachomatis-infected genital epithelial cells. Microbiology 154: 1290-1299 [Abstract] [Full Text]
Mazzon, E., Cuzzocrea, S. (2008). Role of TNF-{alpha} in ileum tight junction alteration in mouse model of restraint stress. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G1268-G1280 [Abstract] [Full Text]
Nishimura, T., Takeichi, M. (2008). Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling. Development 135: 1493-1502 [Abstract] [Full Text]
Xu, J., Kausalya, P. J., Phua, D. C. Y., Ali, S. M., Hossain, Z., Hunziker, W. (2008). Early Embryonic Lethality of Mice Lacking ZO-2, but Not ZO-3, Reveals Critical and Nonredundant Roles for Individual Zonula Occludens Proteins in Mammalian Development. Mol. Cell. Biol. 28: 1669-1678 [Abstract] [Full Text]
Dokladny, K., Ye, D., Kennedy, J. C., Moseley, P. L., Ma, T. Y. (2008). Cellular and Molecular Mechanisms of Heat Stress-Induced Up-Regulation of Occludin Protein Expression: Regulatory Role of Heat Shock Factor-1. Am. J. Pathol. 172: 659-670 [Abstract] [Full Text]
Vagin, O., Tokhtaeva, E., Yakubov, I., Shevchenko, E., Sachs, G. (2008). Inverse Correlation between the Extent of N-Glycan Branching and Intercellular Adhesion in Epithelia: CONTRIBUTION OF THE Na,K-ATPase 1 SUBUNIT. J. Biol. Chem. 283: 2192-2202 [Abstract] [Full Text]
Komura, H., Ogita, H., Ikeda, W., Mizoguchi, A., Miyoshi, J., Takai, Y. (2008). Establishment of cell polarity by afadin during the formation of embryoid bodies.. GENES CELLS 13: 79-90 [Abstract] [Full Text]
Wu, J., Yang, Y., Zhang, J., Ji, P., Du, W., Jiang, P., Xie, D., Huang, H., Wu, M., Zhang, G., Wu, J., Shi, Y. (2007). Domain-swapped Dimerization of the Second PDZ Domain of ZO2 May Provide a Structural Basis for the Polymerization of Claudins. J. Biol. Chem. 282: 35988-35999 [Abstract] [Full Text]
Konopka, G., Tekiela, J., Iverson, M., Wells, C., Duncan, S. A. (2007). Junctional Adhesion Molecule-A Is Critical for the Formation of Pseudocanaliculi and Modulates E-cadherin Expression in Hepatic Cells. J. Biol. Chem. 282: 28137-28148 [Abstract] [Full Text]
Ooshio, T., Fujita, N., Yamada, A., Sato, T., Kitagawa, Y., Okamoto, R., Nakata, S., Miki, A., Irie, K., Takai, Y. (2007). Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J. Cell Sci. 120: 2352-2365 [Abstract] [Full Text]
Matter, K., Balda, M. S. (2007). Epithelial tight junctions, gene expression and nucleo-junctional interplay. J. Cell Sci. 120: 1505-1511 [Abstract] [Full Text]
Sugihara-Mizuno, Y., Adachi, M., Kobayashi, Y., Hamazaki, Y., Nishimura, M., Imai, T., Furuse, M., Tsukita, S. (2007). Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. GENES CELLS 12: 473-486 [Abstract] [Full Text]
Zheng, B., Cantley, L. C. (2007). Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc. Natl. Acad. Sci. USA 104: 819-822 [Abstract] [Full Text]
Vagin, O., Tokhtaeva, E., Sachs, G. (2006). The Role of the beta1 Subunit of the Na,K-ATPase and Its Glycosylation in Cell-Cell Adhesion. J. Biol. Chem. 281: 39573-39587 [Abstract] [Full Text]
Kohno, Y., Okamoto, T., Ishibe, T., Nagayama, S., Shima, Y., Nishijo, K., Shibata, K. R., Fukiage, K., Otsuka, S., Uejima, D., Araki, N., Naka, N., Nakashima, Y., Aoyama, T., Nakayama, T., Nakamura, T., Toguchida, J. (2006). Expression of Claudin7 Is Tightly Associated with Epithelial Structures in Synovial Sarcomas and Regulated by an Ets Family Transcription Factor, ELF3. J. Biol. Chem. 281: 38941-38950 [Abstract] [Full Text]
Nunes, F. D., Lopez, L. N., Lin, H. W., Davies, C., Azevedo, R. B., Gow, A., Kachar, B. (2006). Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J. Cell Sci. 119: 4819-4827 [Abstract] [Full Text]
Adachi, M., Inoko, A., Hata, M., Furuse, K., Umeda, K., Itoh, M., Tsukita, S. (2006). Normal Establishment of Epithelial Tight Junctions in Mice and Cultured Cells Lacking Expression of ZO-3, a Tight-Junction MAGUK Protein. Mol. Cell. Biol. 26: 9003-9015 [Abstract] [Full Text]
Harhaj, N. S., Felinski, E. A., Wolpert, E. B., Sundstrom, J. M., Gardner, T. W., Antonetti, D. A. (2006). VEGF Activation of Protein Kinase C Stimulates Occludin Phosphorylation and Contributes to Endothelial Permeability. IOVS 47: 5106-5115 [Abstract] [Full Text]
Guttman, J. A., Samji, F. N., Li, Y., Vogl, A. W., Finlay, B. B. (2006). Evidence that Tight Junctions Are Disrupted Due to Intimate Bacterial Contact and Not Inflammation during Attaching and Effacing Pathogen Infection In Vivo. Infect. Immun. 74: 6075-6084 [Abstract] [Full Text]
Otani, T., Ichii, T., Aono, S., Takeichi, M. (2006). Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells. JCB 175: 135-146 [Abstract] [Full Text]
Christiansen, J. J., Rajasekaran, A. K. (2006). Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis.. Cancer Res. 66: 8319-8326 [Abstract] [Full Text]
Inagaki, M., Irie, K., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Takai, Y. (2006). Role of cell adhesion molecule nectin-3 in spermatid development.. GENES CELLS 11: 1125-1132 [Abstract] [Full Text]
Petersen, E T, Zimine, I, Ho, Y-C L, Golay, X (2006). Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques. Br. J. Radiol. 79: 688-701 [Abstract] [Full Text]
Emadali, A., Muscatelli-Groux, B., Delom, F., Jenna, S., Boismenu, D., Sacks, D. B., Metrakos, P. P., Chevet, E. (2006). Proteomic Analysis of Ischemia-Reperfusion Injury upon Human Liver Transplantation Reveals the Protective Role of IQGAP1. Mol. Cell. Proteomics 5: 1300-1313 [Abstract] [Full Text]
Balkovetz, D. F. (2006). Claudins at the gate: determinants of renal epithelial tight junction paracellular permeability. Am. J. Physiol. Renal Physiol. 290: F572-F579 [Abstract] [Full Text]
Sato, T., Fujita, N., Yamada, A., Ooshio, T., Okamoto, R., Irie, K., Takai, Y. (2006). Regulation of the Assembly and Adhesion Activity of E-cadherin by Nectin and Afadin for the Formation of Adherens Junctions in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 281: 5288-5299 [Abstract] [Full Text]
Dokladny, K., Moseley, P. L., Ma, T. Y. (2006). Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G204-G212 [Abstract] [Full Text]
Miyawaki-Shimizu, K., Predescu, D., Shimizu, J., Broman, M., Predescu, S., Malik, A. B. (2006). siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L405-L413 [Abstract] [Full Text]
Lillywhite, H. B. (2006). Water relations of tetrapod integument. J. Exp. Biol. 209: 202-226 [Abstract] [Full Text]
Pummi, K. P., Aho, H. J., Laato, M. K., Peltonen, J. T.K., Peltonen, S. A. (2006). Tight Junction Proteins and Perineurial Cells in Neurofibromas. J. Histochem. Cytochem. 54: 53-61 [Abstract] [Full Text]
Lee, D. B. N., Huang, E., Ward, H. J. (2006). Tight junction biology and kidney dysfunction. Am. J. Physiol. Renal Physiol. 290: F20-F34 [Abstract] [Full Text]
Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., Tsukita, S. (2005). Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. JCB 171: 939-945 [Abstract] [Full Text]
Powell, K. (2005). Sticking it out with tight junctions. JCB 171: 916-917 [Full Text]
Tan, X, Egami, H, Abe, M, Nozawa, F, Hirota, M, Ogawa, M (2005). Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway. J. Clin. Pathol. 58: 1242-1248 [Abstract] [Full Text]
Komiya, S., Shimizu, M., Ikenouchi, J., Yonemura, S., Matsui, T., Fukunaga, Y., Liu, H., Endo, F., Tsukita, S., Nagafuchi, A. (2005). Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells. GENES CELLS 10: 1065-1080 [Abstract] [Full Text]
Carrozzino, F., Soulie, P., Huber, D., Mensi, N., Orci, L., Cano, A., Feraille, E., Montesano, R. (2005). Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins. Am. J. Physiol. Cell Physiol. 289: C1002-C1014 [Abstract] [Full Text]
Bruewer, M., Utech, M., Ivanov, A. I., Hopkins, A. M., Parkos, C. A., Nusrat, A. (2005). Interferon-{gamma} induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J. 19: 923-933 [Abstract] [Full Text]
Matlin, K. S. (2005). Clues to occludin. Focus on "Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells". Am. J. Physiol. Cell Physiol. 288: C1191-C1192 [Full Text]
Yu, A. S. L., McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Lynch, R. D., Schneeberger, E. E. (2005). Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am. J. Physiol. Cell Physiol. 288: C1231-C1241 [Abstract] [Full Text]
Miyamoto, T., Morita, K., Takemoto, D., Takeuchi, K., Kitano, Y., Miyakawa, T., Nakayama, K., Okamura, Y., Sasaki, H., Miyachi, Y., Furuse, M., Tsukita, S. (2005). Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice. JCB 169: 527-538 [Abstract] [Full Text]
Okamoto, R., Irie, K., Yamada, A., Katata, T., Fukuhara, A., Takai, Y. (2005). Recruitment of E-cadherin associated with {alpha}- and {beta}-catenins and p120ctn to the nectin-based cell-cell adhesion sites by the action of 12-O-tetradecanoylphorbol-13-acetate in MDCK cells. GENES CELLS 10: 435-445 [Abstract] [Full Text]
Wells, W. A. (2005). Defining junctional complexes. JCB 168: 989-989 [Full Text]
Yamada, A., Irie, K., Hirota, T., Ooshio, T., Fukuhara, A., Takai, Y. (2005). Involvement of the Annexin II-S100A10 Complex in the Formation of E-cadherin-based Adherens Junctions in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 280: 6016-6027 [Abstract] [Full Text]
Vogelmann, R., Nelson, W. J. (2005). Fractionation of the Epithelial Apical Junctional Complex: Reassessment of Protein Distributions in Different Substructures. Mol. Biol. Cell 16: 701-716 [Abstract] [Full Text]
Ohnishi, H., Nakahara, T., Furuse, K., Sasaki, H., Tsukita, S., Furuse, M. (2004). JACOP, a Novel Plaque Protein Localizing at the Apical Junctional Complex with Sequence Similarity to Cingulin. J. Biol. Chem. 279: 46014-46022 [Abstract] [Full Text]
Umeda, K., Matsui, T., Nakayama, M., Furuse, K., Sasaki, H., Furuse, M., Tsukita, S. (2004). Establishment and Characterization of Cultured Epithelial Cells Lacking Expression of ZO-1. J. Biol. Chem. 279: 44785-44794 [Abstract] [Full Text]
Yamada, A., Irie, K., Fukuhara, A., Ooshio, T., Takai, Y. (2004). Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. GENES CELLS 9: 843-855 [Abstract] [Full Text]
Lee, D. B. N., Jamgotchian, N., Allen, S. G., Kan, F. W. K., Hale, I. L. (2004). Annexin A2 heterotetramer: role in tight junction assembly. Am. J. Physiol. Renal Physiol. 287: F481-F491 [Abstract] [Full Text]
Fukuhara, T., Shimizu, K., Kawakatsu, T., Fukuyama, T., Minami, Y., Honda, T., Hoshino, T., Yamada, T., Ogita, H., Okada, M., Takai, Y. (2004). Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. JCB 166: 393-405 [Abstract] [Full Text]
Bazzoni, G., Dejana, E. (2004). Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis. Physiol. Rev. 84: 869-901 [Abstract] [Full Text]
Rahner, C., Fukuhara, M., Peng, S., Kojima, S., Rizzolo, L. J. (2004). The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. J. Cell Sci. 117: 3307-3318 [Abstract] [Full Text]
Schneeberger, E. E., Lynch, R. D. (2004). The tight junction: a multifunctional complex. Am. J. Physiol. Cell Physiol. 286: C1213-C1228 [Abstract] [Full Text]
Ivanov, A. I., McCall, I. C., Parkos, C. A., Nusrat, A. (2004). Role for Actin Filament Turnover and a Myosin II Motor in Cytoskeleton-driven Disassembly of the Epithelial Apical Junctional Complex. Mol. Biol. Cell 15: 2639-2651 [Abstract] [Full Text]
Turksen, K., Troy, T.-C. (2004). Barriers built on claudins. J. Cell Sci. 117: 2435-2447 [Abstract] [Full Text]
Wu, V. M., Schulte, J., Hirschi, A., Tepass, U., Beitel, G. J. (2004). Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. JCB 164: 313-323 [Abstract] [Full Text]
Raschperger, E., Engstrom, U., Pettersson, R. F., Fuxe, J. (2004). CLMP, a Novel Member of the CTX Family and a New Component of Epithelial Tight Junctions. J. Biol. Chem. 279: 796-804 [Abstract] [Full Text]
Ivanov, A. I., Nusrat, A., Parkos, C. A. (2004). Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment. Mol. Biol. Cell 15: 176-188 [Abstract] [Full Text]
Fukuhara, A., Shimizu, K., Kawakatsu, T., Fukuhara, T., Takai, Y. (2003). Involvement of Nectin-activated Cdc42 Small G Protein in Organization of Adherens and Tight Junctions in Madin-Darby Canine Kidney Cells. J. Biol. Chem. 278: 51885-51893 [Abstract] [Full Text]
Straub, B. K., Boda, J., Kuhn, C., Schnoelzer, M., Korf, U., Kempf, T., Spring, H., Hatzfeld, M., Franke, W. W. (2003). A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J. Cell Sci. 116: 4985-4995 [Abstract] [Full Text]
Kansagra, K., Stoll, B., Rognerud, C., Niinikoski, H., Ou, C.-N., Harvey, R., Burrin, D. (2003). Total parenteral nutrition adversely affects gut barrier function in neonatal piglets. Am. J. Physiol. Gastrointest. Liver Physiol. 285: G1162-G1170 [Abstract] [Full Text]
Shimizu, K., Takai, Y. (2003). Roles of the Intercellular Adhesion Molecule Nectin in Intracellular Signaling. J Biochem 134: 631-636 [Abstract] [Full Text]
Rajasekaran, A. K., Rajasekaran, S. A. (2003). Role of Na-K-ATPase in the assembly of tight junctions. Am. J. Physiol. Renal Physiol. 285: F388-F396 [Abstract] [Full Text]
Schneeberger, E. E. (2003). Claudins form ion-selective channels in the paracellular pathway. Focus on "Claudin extracellular domains determine paracellular charge selectively and resistance but not tight junction fibril architecture". Am. J. Physiol. Cell Physiol. 284: C1331-C1333 [Full Text]
Rajasekaran, S. A., Hu, J., Gopal, J., Gallemore, R., Ryazantsev, S., Bok, D., Rajasekaran, A. K. (2003). Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells. Am. J. Physiol. Cell Physiol. 284: C1497-C1507 [Abstract] [Full Text]
Ikenouchi, J., Matsuda, M., Furuse, M., Tsukita, S. (2003). Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J. Cell Sci. 116: 1959-1967 [Abstract] [Full Text]
Sasaki, H., Matsui, C., Furuse, K., Mimori-Kiyosue, Y., Furuse, M., Tsukita, S. (2003). Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc. Natl. Acad. Sci. USA 100: 3971-3976 [Abstract] [Full Text]
Tanaka, Y., Nakanishi, H., Kakunaga, S., Okabe, N., Kawakatsu, T., Shimizu, K., Takai, Y. (2003). Role of Nectin in Formation of E-Cadherin-based Adherens Junctions in Keratinocytes: Analysis with the N-Cadherin Dominant Negative Mutant. Mol. Biol. Cell 14: 1597-1609 [Abstract] [Full Text]
Balda, M. S., Garrett, M. D., Matter, K. (2003). The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. JCB 160: 423-432 [Abstract] [Full Text]
Asada, M., Irie, K., Morimoto, K., Yamada, A., Ikeda, W., Takeuchi, M., Takai, Y. (2003). ADIP, a Novel Afadin- and alpha -Actinin-Binding Protein Localized at Cell-Cell Adherens Junctions. J. Biol. Chem. 278: 4103-4111 [Abstract] [Full Text]
Takai, Y., Nakanishi, H. (2003). Nectin and afadin: novel organizers of intercellular junctions. J. Cell Sci. 116: 17-27 [Abstract] [Full Text]
Shelden, E. A., Weinberg, J. M., Sorenson, D. R., Edwards, C. A., Pollock, F. M. (2002). Site-Specific Alteration of Actin Assembly Visualized in Living Renal Epithelial Cells during ATP Depletion. J. Am. Soc. Nephrol. 13: 2667-2680 [Abstract] [Full Text]
Schubert, W., Frank, P. G., Woodman, S. E., Hyogo, H., Cohen, D. E., Chow, C.-W., Lisanti, M. P. (2002). Microvascular Hyperpermeability in Caveolin-1 (-/-) Knock-out Mice. TREATMENT WITH A SPECIFIC NITRIC-OXIDE SYNTHASE INHIBITOR, L-NAME, RESTORES NORMAL MICROVASCULAR PERMEABILITY IN Cav-1 NULL MICE. J. Biol. Chem. 277: 40091-40098 [Abstract] [Full Text]
Evans, S. M., Blyth, D. I., Wong, T., Sanjar, S., West, M. R. (2002). Decreased Distribution of Lung Epithelial Junction Proteins after Intratracheal Antigen or Lipopolysaccharide Challenge: Correlation with Neutrophil Influx and Levels of BALF sE-Cadherin. Am. J. Respir. Cell Mol. Bio. 27: 446-454 [Abstract] [Full Text]
Cheng, C. Y., Mruk, D. D. (2002). Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development. Physiol. Rev. 82: 825-874 [Abstract] [Full Text]
Hirose, T., Izumi, Y., Nagashima, Y., Tamai-Nagai, Y., Kurihara, H., Sakai, T., Suzuki, Y., Yamanaka, T., Suzuki, A., Mizuno, K., Ohno, S. (2002). Involvement of ASIP/PAR-3 in the promotion of epithelial tight junction formation. J. Cell Sci. 115: 2485-2495 [Abstract] [Full Text]
Park, D. S., Woodman, S. E., Schubert, W., Cohen, A. W., Frank, P. G., Chandra, M., Shirani, J., Razani, B., Tang, B., Jelicks, L. A., Factor, S. M., Weiss, L. M., Tanowitz, H. B., Lisanti, M. P. (2002). Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype. Am. J. Pathol. 160: 2207-2217 [Abstract] [Full Text]
Collins, J E (2002). Adhesion between dendritic cells and epithelial cells maintains the gut barrier during bacterial sampling. Gut 50: 449-450 [Full Text]
Kiuchi-Saishin, Y., Gotoh, S., Furuse, M., Takasuga, A., Tano, Y., Tsukita, S. (2002). Differential Expression Patterns of Claudins, Tight Junction Membrane Proteins, in Mouse Nephron Segments. J. Am. Soc. Nephrol. 13: 875-886 [Abstract] [Full Text]