JCB logo
Accuri Cytometers
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 11 July 2005. doi:10.1083/jcb.200506039
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 170, Number 2, 169-171
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 211K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vecchi, M.
Right arrow Articles by Di Fiore, P. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vecchi, M.
Right arrow Articles by Di Fiore, P. P.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Comment

It's HIP to be a hub

: new trends for old-fashioned proteins



Manuela Vecchi1 and Pier Paolo Di Fiore1,2,3

1 Fondazione Istituto FIRC (Fondazione Italiana per la Ricerca sul Cancro) di Oncologia Molecolare, 20139 Milan, Italy
2 Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, 20122 Milan, Italy
3 Istituto Europeo di Oncologia, 20141 Milan, Italy

Correspondence to Pier Paolo Di Fiore: pierpaolo.difiore{at}ifom-ieo-campus.it


Abstract

Many endocytic proteins shuttle between the nucleus and the cytoplasm; however, their putative function in the nucleus is unclear. Now, new data demonstrate that huntingtin interacting protein 1 (HIP1), an endocytic protein, modulates the transcriptional activity of nuclear hormone receptors. In network theory, therefore, HIP1 can be regarded as a hub connecting heterogeneous functional "territories:" a possibility with important physiological and pathological implications.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors
Ian G. Mills, Luke Gaughan, Craig Robson, Theodora Ross, Stuart McCracken, John Kelly, and David E. Neal
J. Cell Biol. 2005 170: 191-200. [Abstract] [Full Text] [PDF]



This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents