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Published 18 July 2005. doi:10.1083/jcb.200506047
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 170, Number 2, 173-175
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Decoding Ca2+ signals

: a question of timing



Shmuel Muallem

Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390

Correspondence to Shmuel Muallem: shmuel.muallem{at}utsouthwestern.edu


Abstract

Receptor-stimulated Ca2+ signals come in several flavors. The Ca2+ signals can be decoded linearly or by integration of the response. How the duration of the signal conveyed by cytosolic Ca2+ concentration ([Ca2+]i) changes is regulated is not well understood. Liu et al. (Liu, Q., S.A. Walker, D. Gao, J.A. Taylor, Y.-F. Dai, R.S. Arkell, M.D. Bootman, H.L. Roderick, P.J. Cullen, and P.J. Lockyer. 2005. J. Cell Biol. 170:183–190) now report an example of decoding based on the differential regulation of Ras function by two Ca2+-sensitive Ras inhibitors: Ca2+-promoted Ras activator (CAPRI), which extends the duration of the effect of Ca2+ on Ras activity, and Ras GTPase activating-like protein (RASAL), which functions as a linear decoder of the Ca2+ signal.

Abbreviations used in this paper: CAPRI, Ca2+-promoted Ras activator; GAP, GTPase-activating protein; GEF, guanine nucleotide exchange factor; PH, pleckstrin homology; PM, plasma membrane; RASAL, Ras GTPase activating-like protein.


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