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Published 29 August 2005. doi:10.1083/jcb.200506131
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 170, Number 5, 803-812
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Article

Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion



Anne Pacquelet and Pernille Rørth

European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany

Correspondence to Pernille Rørth: rorth{at}EMBL-Heidelberg.de

Cadherin-mediated adhesion can be regulated at many levels, as demonstrated by detailed analysis in cell lines. We have investigated the requirements for Drosophila melanogaster epithelial (DE) cadherin regulation in vivo. Investigating D. melanogaster oogenesis as a model system allowed the dissection of DE-cadherin function in several types of adhesion: cell sorting, cell positioning, epithelial integrity, and the cadherin-dependent process of border cell migration. We generated multiple fusions between DE-cadherin and {alpha}-catenin as well as point-mutated ß-catenin and analyzed their ability to support these types of adhesion. We found that (1) although linking DE-cadherin to {alpha}-catenin is essential, regulation of the link is not required in any of these types of adhesion; (2) ß-catenin is required only to link DE-cadherin to {alpha}-catenin; and (3) the cytoplasmic domain of DE-cadherin has an additional specific function for the invasive migration of border cells, which is conserved to other cadherins. The nature of this additional function is discussed.

Abbreviations used in this paper: arm, armadillo; DE, Drosophila epithelial; FL, full length; JM, juxtamembrane domain; shg, shotgun; UAS, upstream activating sequence.


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