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Aß generation in autophagic vacuoles

Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613, Japan
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

Correspondence to Noboru Mizushima: nmizu{at}rinshoken.or.jp

Abstract

Alzheimer's disease (AD) is the most common form of dementia among older people. It is characterized by the extracellular accumulation of ß-amyloid (Aß) deposits called senile or neuritic plaques. Aß is generated by the proteolytic cleavage of Aß precursor protein (APP) by ß and -secretases localized in the secretory and endocytic compartments. In this issue, Yu et al. (on p. 87) report a novel mechanism for the generation of Aß peptides, which takes place in autophagic vacuoles (AVs) that accumulate in AD brains.

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