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Published online 17 October 2005. doi:10.1083/jcb.200505020
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 171, Number 2, 241-253
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Article

Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae



Anna V. Kateneva1,2, Anton A. Konovchenko1,2, Vincent Guacci3, and Michael E. Dresser1,2

1 Program in Molecular, Cell, and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
2 Department of Cell Biology, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104
3 Basic Science Division, Fox Chase Center, Philadelphia, PA 19111

Correspondence to Michael E. Dresser: dresserm{at}omrf.ouhsc.edu

Sister chromatid cohesion and interhomologue recombination are coordinated to promote the segregation of homologous chromosomes instead of sister chromatids at the first meiotic division. During meiotic prophase in Saccharomyces cerevisiae, the meiosis-specific cohesin Rec8p localizes along chromosome axes and mediates most of the cohesion. The mitotic cohesin Mcd1p/Scc1p localizes to discrete spots along chromosome arms, and its function is not clear. In cells lacking Tid1p, which is a member of the SWI2/SNF2 family of helicase-like proteins that are involved in chromatin remodeling, Mcd1p and Rec8p persist abnormally through both meiotic divisions, and chromosome segregation fails in the majority of cells. Genetic results indicate that the primary defect in these cells is a failure to resolve Mcd1p-mediated connections. Tid1p interacts with recombination enzymes Dmc1p and Rad51p and has an established role in recombination repair. We propose that Tid1p remodels Mcd1p-mediated cohesion early in meiotic prophase to facilitate interhomologue recombination and the subsequent segregation of homologous chromosomes.

Abbreviations used in this paper: DSB, double strand break; SC, synaptonemal complex; SPB, spindle pole body.


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