Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1548K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Marti, M. Articles by Cowman, A. F. Search for Related Content PubMed PubMed Citation Articles by Marti, M. Articles by Cowman, A. F. Social Bookmarking                      What's this?

¹ The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
² Department of Biochemistry, La Trobe University, Melbourne, Victoria 3000, Australia

Correspondence to Alan F. Cowman: cowman{at}wehi.edu.au

Abstract
Intracellular parasites from the genus Plasmodium reside and multiply in a variety of cells during their development. After invasion of human erythrocytes, asexual stages from the most virulent malaria parasite, P. falciparum, drastically change their host cell and export remodelling and virulence proteins. Recent data demonstrate that a specific NH₂-terminal signal conserved across the genus Plasmodium plays a central role in this export process.

Abbreviations used in this paper: DBL, duffy binding-like; iRBC, infected RBC; KAHRP, knob-associated histidine-rich protein; PEXEL, Plasmodium export element; PfEMP, P. falciparum erythrocyte membrane protein; PHIST, Plasmodium helical interspersed subtelomeric family; PVM, parasitophorous vacuole membrane; RESA, ring-infected erythrocyte surface antigen.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Aurrecoechea, C., Brestelli, J., Brunk, B. P., Dommer, J., Fischer, S., Gajria, B., Gao, X., Gingle, A., Grant, G., Harb, O. S., Heiges, M., Innamorato, F., Iodice, J., Kissinger, J. C., Kraemer, E., Li, W., Miller, J. A., Nayak, V., Pennington, C., Pinney, D. F., Roos, D. S., Ross, C., Stoeckert, C. J. Jr., Treatman, C., Wang, H. (2009). PlasmoDB: a functional genomic database for malaria parasites. Nucleic Acids Res 37: D539-D543 [Abstract] [Full Text]  
• Bhattacharjee, S., van Ooij, C., Balu, B., Adams, J. H., Haldar, K. (2008). Maurer's clefts of Plasmodium falciparum are secretory organelles that concentrate virulence protein reporters for delivery to the host erythrocyte. Blood 111: 2418-2426 [Abstract] [Full Text]  
• Francis, S. E., Malkov, V. A., Oleinikov, A. V., Rossnagle, E., Wendler, J. P., Mutabingwa, T. K., Fried, M., Duffy, P. E. (2007). Six Genes Are Preferentially Transcribed by the Circulating and Sequestered Forms of Plasmodium falciparum Parasites That Infect Pregnant Women. Infect. Immun. 75: 4838-4850 [Abstract] [Full Text]  
• Frankland, S., Elliott, S. R., Yosaatmadja, F., Beeson, J. G., Rogerson, S. J., Adisa, A., Tilley, L. (2007). Serum Lipoproteins Promote Efficient Presentation of the Malaria Virulence Protein PfEMP1 at the Erythrocyte Surface. Eukaryot Cell 6: 1584-1594 [Abstract] [Full Text]  
• Pei, X., Guo, X., Coppel, R., Bhattacharjee, S., Haldar, K., Gratzer, W., Mohandas, N., An, X. (2007). The ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum stabilizes spectrin tetramers and suppresses further invasion. Blood 110: 1036-1042 [Abstract] [Full Text]  
• Maier, A. G., Rug, M., O'Neill, M. T., Beeson, J. G., Marti, M., Reeder, J., Cowman, A. F. (2007). Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. Blood 109: 1289-1297 [Abstract] [Full Text]  
• Lavazec, C., Sanyal, S., Templeton, T. J. (2006). Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum. Nucleic Acids Res 0: gkl942v1-12 [Abstract] [Full Text]  
• Treeck, M., Struck, N. S., Haase, S., Langer, C., Herrmann, S., Healer, J., Cowman, A. F., Gilberger, T. W. (2006). A Conserved Region in the EBL Proteins Is Implicated in Microneme Targeting of the Malaria Parasite Plasmodium falciparum. J. Biol. Chem. 281: 31995-32003 [Abstract] [Full Text]  
• Spielmann, T., Hawthorne, P. L., Dixon, M. W.A., Hannemann, M., Klotz, K., Kemp, D. J., Klonis, N., Tilley, L., Trenholme, K. R., Gardiner, D. L. (2006). A Cluster of Ring Stage-specific Genes Linked to a Locus Implicated in Cytoadherence in Plasmodium falciparum Codes for PEXEL-negative and PEXEL-positive Proteins Exported into the Host Cell. Mol. Biol. Cell 17: 3613-3624 [Abstract] [Full Text]  
• Gilson, P. R., Nebl, T., Vukcevic, D., Moritz, R. L., Sargeant, T., Speed, T. P., Schofield, L., Crabb, B. S. (2006). Identification and Stoichiometry of Glycosylphosphatidylinositol-anchored Membrane Proteins of the Human Malaria Parasite Plasmodium falciparum. Mol. Cell. Proteomics 5: 1286-1299 [Abstract] [Full Text]  
• Marti, M., Baum, J., Rug, M., Tilley, L., Cowman, A. F. (2005). Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. JEM 202: i23-23 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents