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Published online 23 January 2006. doi:10.1083/jcb.200512153
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 172, Number 3, 331-333
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Checkpoint control of mitotic exit—do budding yeast mind the GAP?



John A. Cooper and Scott A. Nelson

Department of Cell Biology, Washington University, St. Louis, MO 63110

Correspondence to John A. Cooper: jcooper{at}wustl.edu


Abstract

Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1.

Abbreviations used in this paper: D-SPB, daughter-bound spindle pole body; GAP, GTPase-activating protein; MEN, mitotic exit network; M-SPB, mother-bound spindle pole body.


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