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Fluorescence In Vivo Endomicroscopy
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Published 13 March 2006. doi:10.1083/jcb.200601114
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 172, Number 6, 795-797
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Comment

 Skeletons in the p53 tumor suppressor closet: genetic evidence that p53 blocks bone differentiation and development

Gerard P. Zambetti1, Edwin M. Horwitz2, and Ernestina Schipani3

1 Department of Biochemistry and 2 Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105
3 Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114

Correspondence to Gerard P. Zambetti: gerard.zambetti{at}stjude.org


Abstract
A series of in vitro tissue culture studies indicated that the p53 tumor suppressor promotes cellular differentiation, which could explain its role in preventing cancer. Quite surprisingly, however, two new in vivo studies (Lengner et al., 2006; Wang et al., 2006) provide genetic evidence that p53 blocks osteoblast differentiation and bone development. These interesting results and their biological and clinical implications are the focus of this comment.

Abbreviations used in this paper: MCSF, macrophage colony–stimulating factor; RANKL, receptor activator of nuclear factor {kappa}B ligand.


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