Published online 15 May 2006. doi:10.1083/jcb.200602082
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 173, Number 4, 463-468
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes
Susan M. Millard1,2,3 and
Stephen A. Wood1,2
1 Child Health Research Institute, North Adelaide, South Australia 5006, Australia
2 School of Molecular and Biomedical Science and 3 Centre for the Molecular Genetics of Development, University of Adelaide, South Australia 5005, Australia
Correspondence to Stephen A. Wood: stephen.wood{at}adelaide.edu.au
Ubiquitylation is a key regulator of protein trafficking, and much about the functions of ubiquitin ligases, which add ubiquitin to substrates in this regulation, has recently come to light. However, a clear understanding of ubiquitin-dependent protein localization cannot be achieved without knowledge of the role of deubiquitylating enzymes (DUBs). DUBs, by definition, function downstream in ubiquitin pathways and, as such, have the potential to be the final editors of protein ubiquitylation status, thus determining substrate fate. This paper assimilates the current evidence concerning the substrates and activities of DUBs that regulate protein trafficking.
Abbreviations used in this paper: DUB, deubiquitylating enzyme; EGFR, EGF receptor; MVB, multivesicular body; STAM, signal-transducing adaptor molecule; UCH, ubiquitin COOH-terminal hydrolase; USP, ubiquitin-specific protease.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Martin, S. L., Epperson, L. E., Rose, J. C., Kurtz, C. C., Ane, C., Carey, H. V.
(2008). Proteomic analysis of the winter-protected phenotype of hibernating ground squirrel intestine. Am. J. Physiol. Regul. Integr. Comp. Physiol.
295: R316-R328
[Abstract]
[Full Text]
-
Wainszelbaum, M. J., Charron, A. J., Kong, C., Kirkpatrick, D. S., Srikanth, P., Barbieri, M. A., Gygi, S. P., Stahl, P. D.
(2008). The Hominoid-specific Oncogene TBC1D3 Activates Ras and Modulates Epidermal Growth Factor Receptor Signaling and Trafficking. J. Biol. Chem.
283: 13233-13242
[Abstract]
[Full Text]
-
Butterworth, M. B., Edinger, R. S., Ovaa, H., Burg, D., Johnson, J. P., Frizzell, R. A.
(2007). The Deubiquitinating Enzyme UCH-L3 Regulates the Apical Membrane Recycling of the Epithelial Sodium Channel. J. Biol. Chem.
282: 37885-37893
[Abstract]
[Full Text]
-
Doelling, J. H., Phillips, A. R., Soyler-Ogretim, G., Wise, J., Chandler, J., Callis, J., Otegui, M. S., Vierstra, R. D.
(2007). The Ubiquitin-Specific Protease Subfamily UBP3/UBP4 Is Essential for Pollen Development and Transmission in Arabidopsis. Plant Physiol.
145: 801-813
[Abstract]
[Full Text]
-
Niendorf, S., Oksche, A., Kisser, A., Lohler, J., Prinz, M., Schorle, H., Feller, S., Lewitzky, M., Horak, I., Knobeloch, K.-P.
(2007). Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo. Mol. Cell. Biol.
27: 5029-5039
[Abstract]
[Full Text]
-
Miranda, M., Sorkin, A.
(2007). Regulation of Receptors and Transporters by Ubiquitination: New Insights into Surprisingly Similar Mechanisms. Mol. Interv.
7: 157-167
[Abstract]
[Full Text]
-
Toyoshima, M., Tanaka, N., Aoki, J., Tanaka, Y., Murata, K., Kyuuma, M., Kobayashi, H., Ishii, N., Yaegashi, N., Sugamura, K.
(2007). Inhibition of Tumor Growth and Metastasis by Depletion of Vesicular Sorting Protein Hrs: Its Regulatory Role on E-Cadherin and {beta}-Catenin. Cancer Res.
67: 5162-5171
[Abstract]
[Full Text]
-
Ren, J., Kee, Y., Huibregtse, J. M., Piper, R. C.
(2007). Hse1, a Component of the Yeast Hrs-STAM Ubiquitin-sorting Complex, Associates with Ubiquitin Peptidases and a Ligase to Control Sorting Efficiency into Multivesicular Bodies. Mol. Biol. Cell
18: 324-335
[Abstract]
[Full Text]
