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"HURP on" we're off to the kinetochore!

Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Correspondence to Andrew Wilde: andrew.wilde{at}utoronto.ca

RanGTP has a central role in spindle assembly, but the Ran-regulated factors required to initiate spindle bipolarity and stabilize MT growth toward the chromosomes remain unknown. However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties.

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This article has been cited by other articles:

• Tsai, C.-Y., Chou, C.-K., Yang, C.-W., Lai, Y.-C., Liang, C.-C., Chen, C.-M., Tsai, T.-F. (2008). Hurp Deficiency in Mice Leads to Female Infertility Caused by an Implantation Defect. J. Biol. Chem. 283: 26302-26306 [Abstract] [Full Text]  

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