Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 670K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vader, G. Articles by Lens, S. M.A. Search for Related Content PubMed PubMed Citation Articles by Vader, G. Articles by Lens, S. M.A. Social Bookmarking                            What's this?

The chromosomal passenger complex: guiding Aurora-B through mitosis

Department of Medical Oncology, University Medical Center, 3584 CG Utrecht, Netherlands

Correspondence to Susanne M.A. Lens: S.M.A.Lens{at}med.uu.nl

During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Hall, L. L., Byron, M., Pageau, G., Lawrence, J. B. (2009). AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. JCB 186: 491-507 [Abstract] [Full Text]  
• Bergman, L. M., Birts, C. N., Darley, M., Gabrielli, B., Blaydes, J. P. (2009). CtBPs Promote Cell Survival through the Maintenance of Mitotic Fidelity. Mol. Cell. Biol. 29: 4539-4551 [Abstract] [Full Text]  
• Bohnert, K. A., Chen, J.-S., Clifford, D. M., Vander Kooi, C. W., Gould, K. L. (2009). A Link between Aurora Kinase and Clp1/Cdc14 Regulation Uncovered by the Identification of a Fission Yeast Borealin-Like Protein. Mol. Biol. Cell 20: 3646-3659 [Abstract] [Full Text]  
• Ferri, F., Bouzinba-Segard, H., Velasco, G., Hube, F., Francastel, C. (2009). Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucleic Acids Res 37: 5071-5080 [Abstract] [Full Text]  
• Fu, J., Bian, M., Liu, J., Jiang, Q., Zhang, C. (2009). A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function. Proc. Natl. Acad. Sci. USA 106: 6939-6944 [Abstract] [Full Text]  
• Ryser, S., Dizin, E., Jefford, C. E., Delaval, B., Gagos, S., Christodoulidou, A., Krause, K.-H., Birnbaum, D., Irminger-Finger, I. (2009). Distinct Roles of BARD1 Isoforms in Mitosis: Full-Length BARD1 Mediates Aurora B Degradation, Cancer-Associated BARD1{beta} Scaffolds Aurora B and BRCA2. Cancer Res. 69: 1125-1134 [Abstract] [Full Text]  
• Klein, U. R., Haindl, M., Nigg, E. A., Muller, S. (2009). RanBP2 and SENP3 Function in a Mitotic SUMO2/3 Conjugation-Deconjugation Cycle on Borealin. Mol. Biol. Cell 20: 410-418 [Abstract] [Full Text]  
• Durcan, T. M., Halpin, E. S., Rao, T., Collins, N. S., Tribble, E. K., Hornick, J. E., Hinchcliffe, E. H. (2008). Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis. JCB 181: 595-603 [Abstract] [Full Text]  
• Movshovich, N., Fridman, V., Gerson-Gurwitz, A., Shumacher, I., Gertsberg, I., Fich, A., Hoyt, M. A., Katz, B., Gheber, L. (2008). Slk19-dependent mid-anaphase pause in kinesin-5-mutated cells. J. Cell Sci. 121: 2529-2539 [Abstract] [Full Text]  
• Wang, W., Cronmiller, C., Brautigan, D. L. (2008). Maternal Phosphatase Inhibitor-2 Is Required for Proper Chromosome Segregation and Mitotic Synchrony During Drosophila Embryogenesis. Genetics 179: 1823-1833 [Abstract] [Full Text]  
• Riefler, G. M., Dent, S. Y. R., Schumacher, J. M. (2008). Tousled-mediated Activation of Aurora B Kinase Does Not Require Tousled Kinase Activity in Vivo. J. Biol. Chem. 283: 12763-12768 [Abstract] [Full Text]  
• Li, H., Chen, Q., Kaller, M., Nellen, W., Graf, R., De Lozanne, A. (2008). Dictyostelium Aurora Kinase Has Properties of both Aurora A and Aurora B Kinases. Eukaryot Cell 7: 894-905 [Abstract] [Full Text]  
• Gautschi, O., Heighway, J., Mack, P. C., Purnell, P. R., Lara, P. N. Jr., Gandara, D. R. (2008). Aurora Kinases as Anticancer Drug Targets. Clin. Cancer Res. 14: 1639-1648 [Abstract] [Full Text]  
• Huang, X.-F., Luo, S.-K., Xu, J., Li, J., Xu, D.-R., Wang, L.-H., Yan, M., Wang, X.-R., Wan, X.-B., Zheng, F.-M., Zeng, Y.-X., Liu, Q. (2008). Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood 111: 2854-2865 [Abstract] [Full Text]  
• Gao, S., Giansanti, M. G., Buttrick, G. J., Ramasubramanyan, S., Auton, A., Gatti, M., Wakefield, J. G. (2008). Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. JCB 180: 521-535 [Abstract] [Full Text]  
• Bourhis, E., Hymowitz, S. G., Cochran, A. G. (2007). The Mitotic Regulator Survivin Binds as a Monomer to Its Functional Interactor Borealin. J. Biol. Chem. 282: 35018-35023 [Abstract] [Full Text]  
• Yang, F., Camp, D. G. II, Gritsenko, M. A., Luo, Q., Kelly, R. T., Clauss, T. R. W., Brinkley, W. R., Smith, R. D., Stenoien, D. L. (2007). Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus. J. Cell Sci. 120: 4060-4070 [Abstract] [Full Text]  
• Vader, G., Cruijsen, C. W.A., van Harn, T., Vromans, M. J.M., Medema, R. H., Lens, S. M.A. (2007). The Chromosomal Passenger Complex Controls Spindle Checkpoint Function Independent from Its Role in Correcting Microtubule Kinetochore Interactions. Mol. Biol. Cell 18: 4553-4564 [Abstract] [Full Text]  
• Pandey, R., Heeger, S., Lehner, C. F. (2007). Rapid effects of acute anoxia on spindle kinetochore interactions activate the mitotic spindle checkpoint. J. Cell Sci. 120: 2807-2818 [Abstract] [Full Text]  
• Vanoosthuyse, V., Prykhozhij, S., Hardwick, K. G. (2007). Shugoshin 2 Regulates Localization of the Chromosomal Passenger Proteins in Fission Yeast Mitosis. Mol. Biol. Cell 18: 1657-1669 [Abstract] [Full Text]  
• Vogel, C., Hager, C., Bastians, H. (2007). Mechanisms of Mitotic Cell Death Induced by Chemotherapy-Mediated G2 Checkpoint Abrogation. Cancer Res. 67: 339-345 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents