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Published online 12 June 2006. doi:10.1083/jcb.200604032
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 173, Number 6, 833-837
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 The chromosomal passenger complex: guiding Aurora-B through mitosis

Gerben Vader, René H. Medema, and Susanne M.A. Lens

Department of Medical Oncology, University Medical Center, 3584 CG Utrecht, Netherlands

Correspondence to Susanne M.A. Lens: S.M.A.Lens{at}med.uu.nl

During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex.

Abbreviations used in this paper: BIR, baculovirus IAP repeat; CPC, chromosomal passenger complex; INCENP, inner centromere protein.


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