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Published online 10 July 2006. doi:10.1083/jcb.200603161
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 2, 169-174
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New consensus nomenclature for mammalian keratins



Jürgen Schweizer1, Paul E. Bowden3, Pierre A. Coulombe4, Lutz Langbein2, E. Birgitte Lane5, Thomas M. Magin6, Lois Maltais7, M. Bishr Omary8, David A.D. Parry9, Michael A. Rogers1, and Mathew W. Wright10

1 Section of Normal and Neoplastic Epidermal Differentiation, 2 Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
3 Department of Dermatology, School of Medicine, Cardiff University, Cardiff CF14 4XN, England, UK
4 Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205
5 Centre for Molecular Medicine, Singapore 13867
6 Division of Cell Biochemistry, Institute of Physiological Chemistry, University of Bonn, D-53115 Bonn, Germany
7 Mouse Genomic Nomenclature Committee, Mouse Genomic Informatics, The Jackson Laboratory, Bar Harbor, ME 04609
8 VA Palo Alto Health System and Stanford University School of Medicine, Department of Medicine, Palo Alto, CA 94304
9 Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand
10 Human Genome Organization Gene Nomenclature Committee, The Galton Laboratory, Department of Biology, University College London, London WC1E 6BT, England, UK

Correspondence to Jürgen Schweizer: schweizer{at}dkfz.de

Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.

Abbreviation used in this paper: HGNC, Human Genome Nomenclature Committee.


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