Interactions between heparan sulfate and proteins: the concept of specificity

doi:10.1083/jcb.200604035

Published 31 July 2006. doi:10.1083/jcb.200604035
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 3, 323-327

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Interactions between heparan sulfate and proteins: the concept of specificity

Johan Kreuger¹, Dorothe Spillmann², Jin-ping Li², and Ulf Lindahl²

¹ Rudbeck Laboratory, Department of Genetics and Pathology, and ² Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, SE-75185 Uppsala, Sweden

Correspondence to Ulf Lindahl: Ulf.Lindahl{at}imbim.uu.se

Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chainsthat mediate interactions with growth factors, morphogens, andreceptors. Thus, PGs modulate fundamental processes such ascell survival, division, adhesion, migration, and differentiation.This review summarizes recent biochemical and genetic informationthat sheds new light on the nature of HS–protein binding.Unexpectedly, many interactions appear to depend more on theoverall organization of HS domains than on their fine structure.

Abbreviations used in this paper: EXT, GlcA/GlcNAc transferase;GlcA, glucuronic acid; GlcNAc, N-acetylglucosamine; HS, heparansulfate; IdoA, iduronic acid; NS, N-sulfated; PG, proteoglycan;SAS, N-sulfated/acetylated/sulfated.

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