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Published 14 August 2006. doi:10.1083/jcb.200603156
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 4, 485-490
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Mini-Review

 Phosphoinositide signaling plays a key role in cytokinesis

Chris Janetopoulos1 and Peter Devreotes2

1 Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232
2 Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

Correspondence to Peter Devreotes: pnd{at}jhmi.edu

To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.

Abbreviations used in this paper: ERM, ezrin-radixin-moesin; PIP, phosphoinositide.


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