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Published 28 August 2006. doi:10.1083/jcb.200608014
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 5, 613-614
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When sparks get old



Werner Melzer

Department of Applied Physiology, University of Ulm, D-89069 Ulm, Germany

Correspondence to Werner Melzer: werner.melzer{at}uni-ulm.de


Abstract

Sparks are transient local elevations of Ca ion concentration observed in different types of muscle cells. Such local Ca2+ signals can be provoked in skeletal muscle cells by altering the osmotic pressure of the extracellular solution. In this issue, Weisleder et al. (see p. 639) demonstrate that the Ca2+ response to osmotic stress is substantially altered in aged muscle. The study presents evidence for a link between this finding and a reduced expression of mitsugumin 29 (MG29), a small membrane protein of the sarcoplasmic reticulum (SR).

Abbreviations used in this paper: CICR, Ca-induced Ca release; DHPR, dihydropyridine receptor; MG29, mitsugumin 29; RyR, ryanodine receptor; SR, sarcoplasmic reticulum.


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Related Article

Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release
Noah Weisleder, Marco Brotto, Shinji Komazaki, Zui Pan, Xiaoli Zhao, Thomas Nosek, Jerome Parness, Hiroshi Takeshima, and Jianjie Ma
J. Cell Biol. 2006 174: 639-645. [Abstract] [Full Text] [PDF]



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