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Published 9 October 2006. doi:10.1083/jcb.200604123
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 175, Number 1, 159-168
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Article

Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells



Sandrine Willaime-Morawek1, Raewyn M. Seaberg1, Claudia Batista1, Etienne Labbé2, Liliana Attisano3, Jessica A. Gorski5, Kevin R. Jones5, Angela Kam4, Cindi M. Morshead4, and Derek van der Kooy1

1 Department of Medical Genetics and Microbiology, 2 Department of Medical Biophysics, 3 Department of Biochemistry, and 4 Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada
5 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309

Correspondence to Sandrine Willaime-Morawek: swmorawek{at}gmail.com

Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1IREScre; LacZ/EGFP double-transgenic murine cells from midgestation into adulthood. Lineage tracing in combination with direct cell labeling and time-lapse video microscopy demonstrated that Emx1-lineage embryonic cortical stem cells migrate ventrally into the striatal germinal zone (GZ) perinatally and intermingle with striatal stem cells. Upon integration into the striatal GZ, cortical stem cells down-regulate Emx1 and up-regulate Dlx2, which is a homeobox gene characteristic of the developing striatum and striatal neural stem cells. This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain.

S. Willaime-Morawek and R.M. Seaberg contributed equally to this paper.

Abbreviations used in this paper: E, embryonic day; GABA, {gamma}-aminobutyric acid; GZ, germinal zone; PND, postnatal day.


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