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Published 23 October 2006. doi:10.1083/jcb.200605037
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 175, Number 2, 283-292
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Article

 MyoD-positive epiblast cells regulate skeletal muscle differentiation in the embryo

Jacquelyn Gerhart1, Justin Elder1, Christine Neely1, Jared Schure1, Tage Kvist1, Karen Knudsen2, and Mindy George-Weinstein1

1 Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131
2 Lankenau Institute for Medical Research, Wynnewood, PA 19096

Correspondence to Mindy George-Weinstein: mindyw{at}pcom.edu

MyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3–positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.

Abbreviation used in this paper: BMP, bone morphogenetic protein.


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