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Palmitoylation-dependent protein sorting

Henry Wellcome Laboratory of Cell Biology, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK

Correspondence to Luke H. Chamberlain: l.chamberlain{at}bio.gla.ac.uk

S-palmitoylation is a posttranslational modification that regulates membrane–protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.

Abbreviations used in this paper: AMPA, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; PAT, palmitoyl transferase; PM, plasma membrane.

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