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Sending proteins to dense core secretory granules: still a lot to sort out

Laboratory of Molecular Biochemistry of Hypertension, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada

Correspondence to Timothy L. Reudelhuber: reudelt{at}ircm.qc.ca

The intracellular sorting of peptide hormone precursors to the dense core secretory granules (DCSGs) is essential for their bioactivation. Despite the fundamental importance of this cellular process, the nature of the sorting signals for entry of proteins into DCSGs remains a source of vigorous debate. This review highlights recent discoveries that are consistent with a model in which several protein domains, acting in a cell-specific fashion and at different steps in the sorting process, act in concert to regulate the entry of proteins into DCSGs.

Abbreviations used in this paper: ANF, atrial natriuretic factor; CGA, chromogranin A; CPE, carboxypeptidase E; DCSG, dense core secretory granule; PAM, peptidyl--amidating monooxygenase; POMC, proopiomelanocortin; PTB, polypyrimidine-binding protein.

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