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Published online
doi:10.1083/jcb.200705105
The Journal of Cell Biology, Vol. 177, No. 6, 953-955
The Rockefeller University Press, 0021-9525 $30.00
© Chan
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Myelination: all about Rac ‘n’ roll



Jonah R. Chan

Zilkha Neurogenetic Institute, Department of Biochemistry and Molecular Biology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033

Correspondence to Jonah R. Chan: jonah.chan{at}usc.edu

During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed "radial sorting". Recent findings identify the Rho family GTPase Rac1 as the downstream effector molecule responsible for process extension and lamellipodia formation in Schwann cells, allowing for proper radial sorting and myelination. These findings begin to shed light on our understanding of the distinct and yet essential molecular mechanisms involved in developmental processes preceding myelination.


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