Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 659K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Perlin, J. R. Articles by Talbot, W. S. Search for Related Content PubMed PubMed Citation Articles by Perlin, J. R. Articles by Talbot, W. S. Related Collections Related Article Social Bookmarking                            What's this?

Putting the glue in glia: Necls mediate Schwann cell–axon adhesion

Department of Developmental Biology, Stanford University, Stanford, CA 94305

Correspondence to Julie R. Perlin: jperlin{at}stanford.edu; or William S. Talbot: talbot{at}cmgm.stanford.edu

Interactions between Schwann cells and axons are critical for the development and function of myelinated axons. Two recent studies (see Maurel et al. on p. 861 of this issue; Spiegel et al., 2007) report that the nectin-like (Necl) proteins Necl-1 and -4 are internodal adhesion molecules that are critical for myelination. These studies suggest that Necl proteins mediate a specific interaction between Schwann cells and axons that allows proper communication of the signals that trigger myelination.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Facebook

Reddit

Technorati

Twitter

This article has been cited by other articles:

• Park, J., Liu, B., Chen, T., Li, H., Hu, X., Gao, J., Zhu, Y., Zhu, Q., Qiang, B., Yuan, J., Peng, X., Qiu, M. (2008). Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS. J. Neurosci. 28: 12815-12819 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents